Voyage of theranostic liposomes for imaging and therapy

被引:5
作者
Sachin, Mitkare [1 ]
Sachin, Dolare [1 ]
Dinesh, Sakarkar [2 ]
机构
[1] Swami Ramanand Teerth Marathwada Univ, Sch Pharm, Dept Pharmaceut, Nanded 431606, Maharashtra, India
[2] SN Inst Pharm, Dept Pharmaceut, Pusad, India
关键词
Diagnosis; drug delivery; imaging; liposomes; theranostics; QUANTUM DOTS; INDUCED BREAKDOWN; CONTRAST AGENTS; DOXORUBICIN; DELIVERY; MRI;
D O I
10.1080/14764172.2017.1279331
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Drug delivery is a critical issue in any disease treatment. Nowadays much more effort is being focused on integrating imaging agent and therapeutic drugs in a single formulation to achieve a simultaneous disease diagnosis and targeted drug delivery. This new terminology nanotheranostics' have been used to describe these nanoparticle formulations. In the ancient years, various nanocarriers (liposomes, nanoparticles, dendrimers, micelles, antibodies, etc.) have been studied for targeted delivery of chemical or biological molecules. In these nanocarriers, liposome is largely studied nanoscale delivery systems and offers more advantages than others due to their unique structural properties. This review will highlight theranostic concept as well as some examples of theranostic liposomal formulations in clinical or preclinical stages. We briefly reviewed approaches to formulate theranostic liposomal formulations.
引用
收藏
页码:245 / 249
页数:5
相关论文
共 41 条
[1]   Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine [J].
Al-Jamal, Wafa' T. ;
Kostarelos, Kostas .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :1094-1104
[2]   Quantum dots as cellular probes [J].
Alivisatos, AP ;
Gu, WW ;
Larabell, C .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2005, 7 :55-76
[3]   LONG-CIRCULATING (STERICALLY STABILIZED) LIPOSOMES FOR TARGETED DRUG-DELIVERY [J].
ALLEN, TM .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :215-220
[4]  
ALLEN TM, 1993, LIPOSOME TECHNOLOGY, V3, P59
[5]  
[Anonymous], CLIN TRIALS
[6]   Fluorescence imaging of tumors in vivo [J].
Ballou, B ;
Ernst, LA ;
Waggoner, AS .
CURRENT MEDICINAL CHEMISTRY, 2005, 12 (07) :795-805
[7]   SURROGATE CELLS OR TROJAN HORSES - THE DISCOVERY OF LIPOSOMES [J].
BANGHAM, AD .
BIOESSAYS, 1995, 17 (12) :1081-1088
[8]   NEGATIVE STAINING OF PHOSPHOLIPIDS + THEIR STRUCTURAL MODIFICATION BY-SURFACE ACTIVE AGENTS AS OBSERVED IN ELECTRON MICROSCOPE [J].
BANGHAM, AD ;
HORNE, RW .
JOURNAL OF MOLECULAR BIOLOGY, 1964, 8 (05) :660-&
[9]   Quantum dots to monitor RNAi delivery and improve gene silencing [J].
Chen, AA ;
Derfus, AM ;
Khetani, SR ;
Bhatia, SN .
NUCLEIC ACIDS RESEARCH, 2005, 33 (22) :e190
[10]   Nanoparticle therapeutics: an emerging treatment modality for cancer [J].
Davis, Mark E. ;
Chen, Zhuo ;
Shin, Dong M. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782