Mechanisms and consequences of activation of protein kinase B/Akt

被引：1211
作者：
Downward, J [1 ]
机构：
[1] Imperial Canc Res Fund, London WC2A 3PX, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(98)80149-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Protein ki nase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin. (C) Current Biology Ltd ISSN 0955-0674.
引用
收藏
页码：262 / 267
页数：6
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