Neuronal activity-induced regulation of Lingo-I

被引：33

作者：

Trifunovski, A ^{[1
]}

Josephson, A ^{[1
]}

Ringman, A ^{[1
]}

Brené, S ^{[1
]}

Spenger, C ^{[1
]}

Olson, L ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

来源：

NEUROREPORT | 2004年 / 15卷 / 15期

关键词：

BDNF; hippocampus; kainic acid; myelin inhibitory proteins; neuronal activity;

D O I：

10.1097/00001756-200410250-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that consists of Nogo receptor (NgR), p75NTR, and Lingo-1. Nogo binding activates RhoA, which inhibits axonal outgrowth. Here we assessed Lingo-1 and NgR mRNA levels after delivery of BDNF into the rat hippocampal formation, Lingo-1 mRNA levels in rats subjected to kainic acid (KA) and running in running wheels. Lingo-1 mRNA was not changed by running. However, we found that Lingo-1 mRNA was strongly up-regulated while NgR mRNA was down-regulated in the dentate gyrus in both the BDNF and the KA experiments. Our data demonstrate inverse regulation of NgR and Lingo-1 in these situations, suggesting that Lingo-1 up-regulation is one characteristic of activity-induced neural plasticity responses.

引用

页码：2397 / 2400

页数：4

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