On the range of Hedgehog signaling

被引：49
作者：
Chuang, PT [1 ]
Kornberg, TB
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 05期
关键词：
D O I：
10.1016/S0959-437X(00)00121-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hedgehog (Hh) is a secreted signaling protein that regulates the development of many organ systems. It can travel from its site of synthesis, a process that involves covalent attachment of cholesterol to its carboxyl terminus, proteins with putative sterol sensing domains in both sending and receiving cells, and glycosaminoglycans. Understanding how the movement of Hh is controlled and propelled will be key to understanding how it carries out its essential roles.
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收藏
页码：515 / 522
页数：8
相关论文
共 108 条
[1]   Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death [J].
Ahlgren, SC ;
Bronner-Fraser, M .
CURRENT BIOLOGY, 1999, 9 (22) :1304-1314
[2]  
Alexandre C, 1999, DEVELOPMENT, V126, P5689
[3]   Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins [J].
Alexandre, C ;
Jacinto, A ;
Ingham, PW .
GENES & DEVELOPMENT, 1996, 10 (16) :2003-2013
[4]  
Amin A, 1999, DEVELOPMENT, V126, P2623
[5]   Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas [J].
Apelqvist, A ;
Ahlgren, U ;
Edlund, H .
CURRENT BIOLOGY, 1997, 7 (10) :801-804
[6]   Ci - a complex transducer of the Hedgehog signal [J].
Aza-Blanc, P ;
Kornberg, TB .
TRENDS IN GENETICS, 1999, 15 (11) :458-462
[7]   Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family [J].
Barnes, MR ;
Duckworth, DM ;
Beeley, LJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1998, 19 (10) :399-400
[8]   Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion [J].
Bellaiche, Y ;
The, I ;
Perrimon, N .
NATURE, 1998, 394 (6688) :85-88
[9]  
Bhat KM, 1997, DEVELOPMENT, V124, P1675
[10]   Hedgehog and Wingless induce metameric pattern in the Drosophila visceral mesoderm [J].
Bilder, D ;
Scott, MP .
DEVELOPMENTAL BIOLOGY, 1998, 201 (01) :43-56
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