Spatiotemporal Control of Amyloid-Like A Plaque Formation Using a Multichannel Organic Electronic Device

被引：5

作者：

Gabrielsson, Erik O. ^{[1
]}

Armgarth, Astrid ^{[1
]}

Hammarstrom, Per ^{[2
]}

Nilsson, K. Peter R. ^{[2
]}

Berggren, Magnus ^{[1
]}

机构：

[1] Linkoping Univ, Lab Organ Elect, Dept Sci & Technol, SE-60174 Norrkoping, Sweden

[2] Linkoping Univ, IFM Dept Chem, SE-58183 Linkoping, Sweden

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2016年 / 301卷 / 04期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

amyloid; Alzheimer's disease; bioelectronics; fibrils; luminescent conjugated oligothiophene; optical probes; IN-VITRO; AGGREGATION; PH; MICROFLUIDICS; DELIVERY; FIBRILS;

D O I：

10.1002/mame.201500428

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We herein report on an iontronic device to drive and control A1-40 and A1-42 fibril formation. This system allows kinetic control of A aggregation by regulation of H+ flows. The formed aggregates show both nanometer-sized fibril structure and microscopic growth, thus mimicking senile plaques, at the H+-outlet. Mechanistically we observed initial accumulation of A1-40 likely driven by electrophoretic migration which preceded nucleation of amyloid structures in the accumulated peptide cluster.

引用

页码：359 / 363

页数：5

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