Disease phenotype and diagnostic delay in Saudi patients with primary Sjogren's syndrome An exploratory cross-sectional study

被引：5

作者：

Omair, Mohammed A. ^{[1
]}

AlQahtani, Bashaer S. ^{[3
]}

AlHamad, Esam H. ^{[2
]}

Tashkandy, Yusra A. ^{[4
]}

Othman, Nashwa S. ^{[5
]}

AlShahrani, Khalid A. ^{[6
]}

Paramasivam, Muthurajan P. ^{[2
]}

AlEnzi, Fahidah ^{[7
]}

Halwani, Rabih ^{[8
]}

Daghestani, Maha H. ^{[3
]}

机构：

[1] King Saud Univ, Rheumatol Div, Dept Med, Coll Med, Riyadh, Saudi Arabia

[2] King Saud Univ, Pulm Div, Dept Med, Coll Med, Riyadh, Saudi Arabia

[3] King Saud Univ, Dept Zool, Coll Med, Riyadh, Saudi Arabia

[4] King Saud Univ, Dept Stat & Operat Res, Coll Sci, Riyadh, Saudi Arabia

[5] King Saud Univ, Cent Lab, Riyadh, Saudi Arabia

[6] Diriyah Gen Hosp, Minist Hlth, Dept Med, Rheumatol Div, Diriyah, Saudi Arabia

[7] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Clin Sci, Riyadh, Saudi Arabia

[8] Univ Sharjah, Sharjah Inst Med Res, Coll Med, Dept Clin Sci, Sharjah, U Arab Emirates

来源：

SAUDI MEDICAL JOURNAL | 2021年 / 42卷 / 04期

关键词：

Sjogren's syndrome; disease phenotype; diagnosis; Saudi; primary; CLINICAL-MANIFESTATIONS; PREVALENCE; FATIGUE;

D O I：

10.15537/smj.2021.42.4.20200767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To describe primary Sjogren's syndrome (pSS) cohort in Saudi Arabiain view in of clinical/serological/histopathological phentotype, and, diagnostic delay. Methods: A cross-sectional study conducted between October 2018 and May 2019. Diagnostic delay was calculated from symptoms onset to clinical diagnosis. The European League Against Rheumatism (EULAR) Sjogren's Syndrome Disease Activity Index (ESSDAI) and EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI) were calculated. Results: Forty-one patients were included in the study. There were predominantly females (78%) with a mean (+/- SD) age of 58.76 +/- 12.7 and disease duration of 4.6 +/- 2.28 years. The mean diagnostic delay was 2.2 +/- 2.4 (range 1-11) years. Minor salivary gland biopsy was performed on 38 (92.7%) patients with a mean focus score of 2.3 +/- 1.2 points. Interstitial lung disease and arthritis were the most common extra-glandular manifestations (EGM) affecting 27 (65.9%) patients for both. The mean ESSDAI was 9.95 +/- 7.73 and ESSPRI was 5.17 +/- 2.4. Conclusion: Saudi primary Sjogren's syndrome patients have a high prevalence of EGM predominantly arthritis and ILD. The diagnostic delay is variable in our cohort.

引用

页码：405 / 410

页数：6

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