JMJD3 in the regulation of human diseases

被引：84
作者：
Zhang, Xiangxian [1 ]
Liu, Li [1 ]
Yuan, Xia [1 ]
Wei, Yuquan [1 ]
Wei, Xiawei [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Lab Aging Res & Nanotoxicol,State Key Lab Biother, Chengdu 610041, Sichuan, Peoples R China
来源：
PROTEIN & CELL | 2019年 / 10卷 / 12期
基金：
中国国家自然科学基金;
关键词：
histone methylation; JMJD3; epigenetics; human diseases; NF-KAPPA-B; HISTONE DEMETHYLASE JMJD3; GENOME-WIDE ANALYSIS; GENE-EXPRESSION; EPIGENETIC REGULATION; H3K27ME3; DEMETHYLASE; MACROPHAGE POLARIZATION; INFLAMMATORY GENES; INK4A-ARF LOCUS; VITAMIN-D;
D O I：
10.1007/s13238-019-0653-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
引用
收藏
页码：864 / 882
页数：19
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