Synthesis of 2-ethoxycarbonyl-2-bromo-4-methyl-4-substituted butanolides and new spiroheteryl-joint butanolides based thereon

被引：4

作者：

Kochikyan, T ^{[1
]}

机构：

[1] Yerevan State Univ, Dept Chem, Yerevan 375025, Armenia

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 22期

关键词：

benzimidazole; benzthiazole; bromolactone; lactone; spiroheterocycle;

D O I：

10.1081/SCC-200036633

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bromination reaction of 2-ethoxycarbonyl-4-methyl-4-substituted butanolides has been studied, and it has been established that bromination with equimolar quantity of bromine in dry carbon tetrachloride was obtained in good yields of 2-ethoxycarbonyl-2-bromo-4-methyl-4-substituted butanolides. The interaction of the latter with thiourea and substituted thioureas has been investigated. It has been shown that under conditions of Hunch's reaction, as a result of heterocyclization were obtained spiroheteryl joint lactones of a new generation-2-aza-3-amino or substituted amino-4-thia-7-oxa-8-methyl-8-substituted spiro[4,4]-2-, nonene-1,6-diones.

引用

页码：4219 / 4225

页数：7