Studies of the total synthesis of epothilone B and D: A facile synthesis of C7-C14 and C15-C21 fragments

被引：0

作者：

Zhang, HS ^{[1
]}

Zhong, CF ^{[1
]}

Bao, XP ^{[1
]}

机构：

[1] Hubei Univ, Dept Chem, Wuhan 430062, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2003年 / 14卷 / 02期

关键词：

epothilone B and D; anticancer drugs; nerol; synthesis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone 13 and D is described in which racemic C7-C14 fragment is prepared from nerol through lour steps, and C15-C21 fragment is obtained from 1,3-dichloroacetone, thioacetamide and propionaldehyde.

引用

页码：115 / 117

页数：3

共 6 条

[1] Total syntheses of epothilones B and D [J].