Synthesis, surface and antimicrobial properties of some quaternary ammonium homochiral camphor sulfonamides

被引：24

作者：

Miklas, R. ^{[1
]}

Miklasova, N. ^{[1
]}

Bukovsky, M. ^{[2
]}

Horvath, B. ^{[3
]}

Kubincova, J. ^{[1
]}

Devinsky, F. ^{[1
]}

机构：

[1] Comenius Univ, Fac Pharm, Dept Chem Theory Drugs, Bratislava 83232, Slovakia

[2] Comenius Univ, Fac Pharm, Dept Cell & Mol Biol Drugs, Bratislava 83232, Slovakia

[3] Comenius Univ, Fac Pharm, NMR Lab, Bratislava 83232, Slovakia

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2014年 / 65卷

关键词：

Quaternary ammonium salts; Antimicrobial activity; Homochiral camphorsulfonamides; Critical micelle concentration; ANTIBACTERIAL ACTIVITY; ESSENTIAL OILS; SALTS; DERIVATIVES; HIV;

D O I：

10.1016/j.ejps.2014.08.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A group of homochiral quaternary ammonium sulfonamides bearing hydrophobic camphor derived moieties were synthesized and characterized. The described synthetic procedure is quick and efficient. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents. They exhibited strong antimicrobial and also antifungal activity, especially N-(2-[((1S, 4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methylsulfonamido] ethyl)-N,N-dimethyltetradecan-1-aminium bromide 1c. The surface properties of prepared compounds were evaluated by surface tension measurements and critical micelle concentration (CMC) with surface tension at CMC (gamma(CMC)) was calculated. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：29 / 37

页数：9

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