A stepwise one-pot synthesis of aryl N-phosphonamidothionate derivatives of nucleosides

被引：1
作者：
Miao, ZW
Fu, H
Tu, GZ
Zhu, JG
Ai, HW
Zhao, YF [1 ]
机构：
[1] Tsing Hua Univ, Sch Life Sci & Engn, Key Lab Bioorgan Phosphorus Chem, Minist Educ,Dept Chem, Beijing 100084, Peoples R China
[2] Beijing Inst Microchem, Beijing 100091, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2003年 / 14卷 / 01期
关键词：
D O I：
10.1002/hc.10080
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel aryl N-phosphonamidothionate derivatives of nucleosides as membrane-soluble pro-drugs of bioactive free nucleotides have been prepared by phosphochloridothioate chemistry. Unprotected nucleosides, for example uridine and adenosine, were used; phosphorylation took place selectively at the 5'-position. (C) 2003 Wiley Periodicals, Inc.
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页码：62 / 66
页数：5
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