Solid Tumor Embolotherapy in Hepatic Arteries with an Anti-reflux Catheter System

被引:17
作者
Xu, Zelin [1 ]
Jernigan, Shaphan [1 ]
Kleinstreuer, Clement [1 ,2 ,3 ]
Buckner, Gregory D. [1 ,2 ,3 ]
机构
[1] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA
[2] N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA
[3] Univ N Carolina, Raleigh, NC 27695 USA
关键词
Liver cancer; Transient particle-hemodynamics; Embolization; Particle-reflux; Infusion-stop point; Excessive particle capture; SUREFIRE INFUSION SYSTEM; COIL EMBOLIZATION; BLOOD-FLOW; HEPATOCELLULAR-CARCINOMA; Y-90; RADIOEMBOLIZATION; MICROSPHERES;
D O I
10.1007/s10439-015-1411-7
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Unresectable hepatoma accounts for the majority of malignant liver tumor cases for which embolization therapy is considered a viable treatment option. However, the potential risk of aberrant particle deposition in non-target regions could cause severe side-effects, alongside diminished efficacy. A computational model has been developed to analyze the particle-hemodynamics before and after deployment of an FDA-approved anti-reflux catheter. The catheter features a retractable, porous cone-like tip designed to allow forward blood flow while preventing microsphere reflux. A patient-specific hepatic artery system, with different daughter branches connected to a liver tumor, was chosen as a representative test bed. In vitro as well as in vivo measurements were used to validate the computer simulation model. The model captures the effect of tip-deployment on blood perfusion and pressure drop in an interactive manner under physiologically realistic conditions. A relationship between the pressure drop and embolization level was established, which can be used to provide clinicians with real-time information on the best infusion-stop point. However, the results show that the present procedure for embolization of downstream vessels which feed a tumor is quite arbitrary. Nevertheless, a method to recycle aberrant particles captured by the deployed tip was proposed to minimize side-effects.
引用
收藏
页码:1036 / 1046
页数:11
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