Leukemia

被引：149

作者：

Juliusson, Gunnar ^{[1
,2
]}

Hough, Rachael ^{[3
]}

机构：

[1] Skane Univ Hosp, Dept Hematol & Oncol, Lund, Sweden

[2] Lund Univ, Stem Cell Ctr, Dept Lab Med, Lund, Sweden

[3] Univ Coll London Hosp NHS Fdn Trust, Dept Adolescent Hematol, 250 Euston Rd, London NW1 2PG, England

来源：

TUMORS IN ADOLESCENTS AND YOUNG ADULTS | 2016年 / 43卷

关键词：

ACUTE-LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; YOUNG-ADULTS; PEDIATRIC PROTOCOL; ADOLESCENTS; CANCER; CHILDREN; AML; CHROMOSOME; REMISSION;

D O I：

10.1159/000447076

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leukemias are a group of life threatening malignant disorders of the blood and bone marrow. In the adolescent and young adult (AYA) population, the acute leukemias are most prevalent, with chronic myeloid leukemia being infrequently seen. Factors associated with more aggressive disease biology tend to increase in frequency with increasing age, whilst tolerability of treatment strategies decreases. There are also challenges regarding the effective delivery of therapy specific to the AYA group, consequences on the unique psychosocial needs of this age group, including compliance. This chapter reviews the current status of epidemiology, pathophysiology, treatment strategies and outcomes of AYA leukemia, with a focus on acute lymphoblastic leukemia and acute myeloid leukemia. (C) 2016 S. Karger AG, Basel

引用

页码：87 / 100

页数：14

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