Engineering CAR-T cells

被引：408

作者：

Zhang, Cheng ^{[1
]}

Liu, Jun ^{[1
]}

Zhong, Jiang F. ^{[2
,3
]}

Zhang, Xi ^{[1
]}

机构：

[1] Third Mil Med Univ, Xinqiao Hosp, Dept Hematol, Chongqing 400037, Peoples R China

[2] Univ Southern Calif, Div Periodontol Diagnost Sci & Dent Hyg, Ostrow Sch Dent, Los Angeles, CA USA

[3] Univ Southern Calif, Div Biomed Sci, Ostrow Sch Dent, Los Angeles, CA USA

来源：

BIOMARKER RESEARCH | 2017年 / 5卷

关键词：

Chimeric antigen receptor redirected T cells; CAR-T cells; Structure; Evolution; Production; Viral vector; CHIMERIC ANTIGEN RECEPTOR; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; ACTIVATION; EXPRESSION; CANCER; LYMPHOCYTES; DOMAINS; VECTORS; IMMUNOGLOBULIN;

D O I：

10.1186/s40364-017-0102-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients' or donors' blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.

引用

页数：6

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