Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma

被引:5
作者
Liu, Chengming [1 ]
Zheng, Sufei [1 ]
Wang, Sihui [1 ]
Wang, Xinfeng [1 ]
Feng, Xiaoli [2 ]
Sun, Nan [1 ]
He, Jie [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Thorac Surg, Natl Canc Ctr, Natl Clin Res Ctr,Canc Hosp, Beijing 100021, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Dept Pathol, Natl Canc Ctr, Natl Clin Res Ctr,Canc Hosp, Beijing, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
East Asians; EGFR; immunophenotype; lung adenocarcinoma; prognosis; GENE-MUTATIONS; CANCER RISK; SIGNATURE; CONTEXTURE; HALLMARKS; REVEALS; COOKING; IMPACT; FUMES; KRAS;
D O I
10.1177/17588359211006949
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: EGFR mutation is a common oncogene driver in East Asians with lung adenocarcinoma (LUAD), conferring a favorable prognosis with effective targeted therapy. However, the EGFR mutation is a weak predictor of long-term survival. Therefore, a powerful predictive tool is urgently needed to estimate disease prognosis and patient survival for East-Asian patients with LUAD. Methods: In this first systematic analysis of the relationships among EGFR mutation, immunophenotype, and prognosis in LUAD samples from East-Asian patients, we constructed a prognostic signature consisting of EGFR-associated immune-related gene pairs (EIGPs). The predictive performance for overall survival (OS) and the clinical significance of this signature were then comprehensively investigated. Results: Based on transcriptome data analysis of a training set, we proposed the EIGP index (EIGPI), represented by five EIGPs, which was significantly associated with the OS of East-Asian patients with LUAD. It was also well validated in a test set. Furthermore, the prognostic performance of the EIGPI was further verified using protein levels in an additional independent set. Stratification analysis and multivariate Cox regression analysis revealed that the EIGPI was an independent prognostic factor. When combined with stage, the composite immune-clinical prognostic model index (ICPMI) showed improved prognostic accuracy in all datasets. Conclusion: This study was the first to systematically investigate the relationships among EGFR mutation, immunophenotype, and prognosis in East Asians with LUAD and develop a composite clinical and immune model associated with EGFR mutation. This model may be a reliable and promising prognostic tool and help further personalize patient management.
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页数:16
相关论文
共 55 条
[1]   A novel prognostic two-gene signature for triple negative breast cancer [J].
Alsaleem, Mansour A. ;
Ball, Graham ;
Toss, Michael S. ;
Raafat, Sara ;
Aleskandarany, Mohammed ;
Joseph, Chitra ;
Ogden, Angela ;
Bhattarai, Shristi ;
Rida, Padmashree C. G. ;
Khani, Francesca ;
Davis, Melissa ;
Elemento, Olivier ;
Aneja, Ritu ;
Ellis, Ian O. ;
Green, Andrew ;
Mongan, Nigel P. ;
Rakha, Emad .
MODERN PATHOLOGY, 2020, 33 (11) :2208-2220
[2]   From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer [J].
Angel, Helen ;
Galon, Jerome .
CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (02) :261-267
[3]   Mechanisms of immune evasion in breast cancer [J].
Bates, Joshua P. ;
Derakhshandeh, Roshanak ;
Jones, Laundette ;
Webb, Tonya J. .
BMC CANCER, 2018, 18
[4]   ImmPort: disseminating data to the public for the future of immunology [J].
Bhattacharya, Sanchita ;
Andorf, Sandra ;
Gomes, Linda ;
Dunn, Patrick ;
Schaefer, Henry ;
Pontius, Joan ;
Berger, Patty ;
Desborough, Vince ;
Smith, Tom ;
Campbell, John ;
Thomson, Elizabeth ;
Monteiro, Ruth ;
Guimaraes, Patricia ;
Walters, Bryan ;
Wiser, Jeff ;
Butte, Atul J. .
IMMUNOLOGIC RESEARCH, 2014, 58 (2-3) :234-239
[5]   Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas [J].
Campbell, Joshua D. ;
Alexandrov, Anton ;
Kim, Jaegil ;
Wala, Jeremiah ;
Berger, Alice H. ;
Pedamallu, Chandra Sekhar ;
Shukla, Sachet A. ;
Guo, Guangwu ;
Brooks, Angela N. ;
Murray, Bradley A. ;
Imielinski, Marcin ;
Hu, Xin ;
Ling, Shiyun ;
Akbani, Rehan ;
Rosenberg, Mara ;
Cibulskis, Carrie ;
Ramachandran, Aruna ;
Collisson, Eric A. ;
Kwiatkowski, David J. ;
Lawrence, Michael S. ;
Weinstein, John N. ;
Verhaak, Roel G. W. ;
Wu, Catherine J. ;
Hammerman, Peter S. ;
Cherniack, Andrew D. ;
Getz, Gad ;
Artyomov, Maxim N. ;
Schreiber, Robert ;
Govindan, Ramaswamy ;
Meyerson, Matthew .
NATURE GENETICS, 2016, 48 (06) :607-+
[6]  
Cancer Genome Atlas Research Network, 2018, Nature, V559, pE12, DOI [10.1038/nature13385, 10.1038/s41586-018-0228-6]
[7]   Genomic landscape of lung adenocarcinoma in East Asians [J].
Chen, Jianbin ;
Yang, Hechuan ;
Teo, Audrey Su Min ;
Amer, Lidyana Bte ;
Sherbaf, Faranak Ghazi ;
Tan, Chu Quan ;
Alvarez, Jacob Josiah Santiago ;
Lu, Bingxin ;
Lim, Jia Qi ;
Takano, Angela ;
Nahar, Rahul ;
Lee, Yin Yeng ;
Phual, Cheryl Zi Jin ;
Chua, Khi Pin ;
Suteja, Lisda ;
Chen, Pauline Jieqi ;
Chang, Mei Mei ;
Koh, Tina Puay Theng ;
Ong, Boon-Hean ;
Anantham, Devanand ;
Hsu, Anne Ann Ling ;
Gogna, Apoorva ;
Too, Chow Wei ;
Aung, Zaw Win ;
Lee, Yi Fei ;
Wang, Lanying ;
Lim, Tony Kiat Hon ;
Wilm, Andreas ;
Choi, Poh Sum ;
Ng, Poh Yong ;
Toh, Chee Keong ;
Lim, Wan-Teck ;
Ma, Siming ;
Lim, Bing ;
Liu, Jin ;
Tam, Wai Leong ;
Skanderup, Anders Jacobsen ;
Yeong, Joe Poh Sheng ;
Tan, Eng-Huat ;
Creasy, Caretha L. ;
Tan, Daniel Shao Weng ;
Hillmer, Axel M. ;
Zhai, Weiwei .
NATURE GENETICS, 2020, 52 (02) :177-+
[8]   Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression [J].
Chen, Yi-Ju ;
Roumeliotis, Theodoros, I ;
Chang, Ya-Hsuan ;
Chen, Ching-Tai ;
Han, Chia-Li ;
Lin, Miao-Hsia ;
Chen, Huei-Wen ;
Chang, Gee-Chen ;
Chang, Yih-Leong ;
Wu, Chen-Tu ;
Lin, Mong-Wei ;
Hsieh, Min-Shu ;
Wang, Yu-Tai ;
Chen, Yet-Ran ;
Jonassen, Inge ;
Ghavidel, Fatemeh Zamanzad ;
Lin, Ze-Shiang ;
Lin, Kuen-Tyng ;
Chen, Ching-Wen ;
Sheu, Pei-Yuan ;
Hung, Chen-Ting ;
Huang, Ke-Chieh ;
Yang, Hao-Chin ;
Lin, Pei-Yi ;
Yen, Ta-Chi ;
Lin, Yi-Wei ;
Wang, Jen-Hung ;
Raghav, Lovely ;
Lin, Chien-Yu ;
Chen, Yan-Si ;
Wu, Pei-Shan ;
Lai, Chi-Ting ;
Weng, Shao-Hsing ;
Su, Kang-Yi ;
Chang, Wei-Hung ;
Tsai, Pang-Yan ;
Robles, Ana, I ;
Rodriguez, Henry ;
Hsiao, Yi-Jing ;
Chang, Wen-Hsin ;
Sung, Ting-Yi ;
Chen, Jin-Shing ;
Yu, Sung-Liang ;
Choudhary, Jyoti S. ;
Chen, Hsuan-Yu ;
Yang, Pan-Chyr ;
Chen, Yu-Ju .
CELL, 2020, 182 (01) :226-+
[9]   The International Epidemiology of Lung Cancer: Latest Trends, Disparities, and Tumor Characteristics [J].
Cheng, Ting-Yuan David ;
Cramb, Susanna M. ;
Baade, Peter D. ;
Youlden, Danny R. ;
Nwogu, Chukwumere ;
Reid, Mary E. .
JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (10) :1653-1671
[10]   Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap) [J].
Dearden, S. ;
Stevens, J. ;
Wu, Y. -L. ;
Blowers, D. .
ANNALS OF ONCOLOGY, 2013, 24 (09) :2371-2376