A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development

被引：6

作者：

Cha, Boksik ^{[1
]}

Moon, Sungjin ^{[2
]}

Kim, Wantae ^{[3
]}

机构：

[1] Daegu Gyeongbuk Med Innovat Fdn, Daegu 41061, South Korea

[2] Kangwon Natl Univ, Dept Biol Sci, Chunchon 24341, South Korea

[3] Chungnam Natl Univ, Dept Biochem, Daejeon 34134, South Korea

来源：

BMB REPORTS | 2021年 / 54卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Hippo signaling pathway; Lymphatic endothelial cells (LECs); Lymphatic vascular development; PROX1; TAZ; VEGF-C/VEGFR3; YAP; GROWTH-FACTOR-C; WNT/BETA-CATENIN; CELL-PROLIFERATION; VESSEL DEVELOPMENT; VALVE DEVELOPMENT; PROX1; EXPRESSION; TEAD/TEF FAMILY; PROTEIN-KINASE; VE-CADHERIN; YAP;

D O I：

10.5483/BMBRep.2021.54.6.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

引用

页码：285 / 294

页数：10

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