Digital-to-biological converter for on-demand production of biologics

被引：51

作者：

Boles, Kent S. ^{[1
]}

Kannan, Krishna ^{[1
]}

Gill, John ^{[1
]}

Felderman, Martina ^{[1
]}

Gouvis, Heather ^{[1
]}

Hubby, Bolyn ^{[1
]}

Kamrud, Kurt I. ^{[1
]}

Venter, J. Craig ^{[1
]}

Gibson, Daniel G. ^{[1
]}

机构：

[1] Synthet Genom Inc, La Jolla, CA 92037 USA

来源：

NATURE BIOTECHNOLOGY | 2017年 / 35卷 / 07期

关键词：

MOLECULES; REPRAP;

D O I：

10.1038/nbt.3859

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization(1-3). We report the development of a digital-to-biological converter for fully automated, versatile and demand-based production of functional biologics starting from DNA sequence information. Specifically, DNA templates, RNA molecules, proteins and viral particles were produced in an automated fashion from digitally transmitted DNA sequences without human intervention.

引用

页码：672 / +

页数：7

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