Photobiomodulation Therapy in Burn Wound Healing: Systematic Review and Meta-Analysis of Preclinical Studies

被引：11

作者：

Figueiredo Deana, Naira ^{[1
,2
,3
]}

Alves, Nilton ^{[4
,5
]}

Zaror, Carlos ^{[1
,2
,6
]}

del Sol, Mariano ^{[4
]}

Salvador Bagnato, Vanderlei ^{[7
]}

机构：

[1] Univ La Frontera, Fac Dent, Ctr Res Epidemiol Econ & Oral Publ Hlth CIEESPO, Temuco, Chile

[2] Univ La Frontera, Fac Dent, Dept Pediat Dent & Orthodont, Temuco, Chile

[3] Univ La Frontera, Doctoral Program Morphol Sci, Temuco, Chile

[4] Univ La Frontera, Fac Med, Ctr Excellence Surg & Morphol Res CEMyQ, Temuco, Chile

[5] Univ La Frontera, Fac Dent, Appl Morphol Res Ctr CIMA, 1145 Francisco Salazar Ave,POB 54-D, Temuco 4780000, Chile

[6] Univ San Sebastian Puerto Montt, Fac Dent, Puerto Montt, Los Lagos, Chile

[7] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP, Brazil

来源：

PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY | 2021年 / 39卷 / 07期

关键词：

photobiomodulation therapy; burn; wound healing; wound contraction; preclinical study; LEVEL LASER THERAPY; LOW-POWER LASER; 3RD-DEGREE BURNS; RED LASER; INFLAMMATORY RESPONSE; PHOTODYNAMIC THERAPY; 2ND-DEGREE BURNS; TISSUE-REPAIR; SKIN BURNS; LIGHT;

D O I：

10.1089/photob.2020.4972

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background and objective: To determine the effectiveness of photobiomodulation therapy (PBMT) in the burn wound healing compared with the control or with the use of antibiotics, in animal models. Materials and methods: A systematic search was conducted in EMBASE, MEDLINE, and LILACS databases. Preclinical studies were included that analyzed the effectiveness of PBMT in the burn wound healing, which assessed wound contraction, angiogenesis, proliferation of fibroblasts, and collagen deposition. SYRCLE risk of bias tool was used. Random effects models were used to estimate the pooled effect. Results: Thirty-eight studies were included. PBMT favored wound contraction (mean difference = -11.47, 95% confidence interval -19.87 to -3.08, I-2 = 0%; moderate certainty of evidence). PBMT also favored angiogenesis at doses between 11 and 20 J/cm(2), and increased the collagenization rate. Conclusions: In animal models, PBMT favored wound contraction, angiogenesis, and collagen deposition in second- and third-degree burn wounds.

引用

页码：439 / 452

页数：14

共 65 条

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