Macrophage Activation in HIV-2-Infected Patients Is Less Affected by Antiretroviral Treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients

被引：8

作者：

Honge, Bo L. ^{[1
,2
,3
]}

Andersen, Morten N. ^{[4
,5
]}

Jespersen, Sanne ^{[2
,3
]}

Medina, Candida ^{[6
]}

Correira, Faustino G. ^{[6
]}

Jakobsen, Martin R. ^{[5
]}

Laursen, Alex ^{[3
]}

Erikstrup, Christian ^{[1
]}

Moller, Holger J. ^{[4
]}

Wejse, Christian ^{[2
,3
,7
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Immunol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[2] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau

[3] Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark

[4] Aarhus Univ Hosp, Dept Clin Biochem, DK-8000 Aarhus, Denmark

[5] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[6] Minist Hlth, Natl HIV Programme, Bissau, Guinea Bissau

[7] Aarhus Univ, Sch Publ Hlth, Ctr Global Hlth, GloHAU, Aarhus, Denmark

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HIV; HIV-1; HIV-2; AIDS; CRP; sCD163; Guinea-Bissau; Africa; GUINEA-BISSAU; CD163;

D O I：

10.1097/QAI.0000000000000939

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The course of disease among HIV-2, HIV-1, and HIV-1/2 dually infected patients is different. We investigated the macrophage activation marker soluble CD163 (sCD163) dynamics in 212 HIV-1, HIV-2, and HIV-1/2 dually infected patients. There were no differences in sCD163 levels at baseline or during follow-up without antiretroviral therapy (ART). At follow-up on ART, median sCD163 levels were decreased for HIV-1-infected patients (P < 0.001), but not among HIV-2 (P = 0.093) or HIV-1/2 dually infected patients (P = 0.145). The larger decrease in sCD163 levels among HIV-1-infected patients during ART may indicate an HIV type-dependent differential effect of ART on macrophage activation during HIV infection.

引用

收藏

页码：254 / 258

页数：5

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