The impact of intrauterine infection on fetal brain damage assessed by S100B protein concentrations in umbilical cord arteries

被引：6

作者：

Masaoka, Naoki ^{[1
]}

Nakajima, Yoshiyuki ^{[1
]}

Morooka, Masako ^{[1
]}

Tashiro, Hidefumi ^{[1
]}

Wada, Masami ^{[1
]}

Maruta, Kana ^{[1
]}

Iwane, Eriko ^{[1
]}

Yamashiro, Miwako ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Yachiyo Med Ctr, Dept Obstet & Gynecol, 477-96 Owada Shinden, Chiba 2768524, Japan

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2016年 / 29卷 / 15期

关键词：

Fetal brain damage; intrauterine infection; S100B protein; CEREBRAL-PALSY; SERUM S100B; AMNIOTIC-FLUID; TERM INFANTS; CHORIOAMNIONITIS; CYTOKINES; NEWBORNS; LESIONS; INJURY; AGE;

D O I：

10.3109/14767058.2015.1087501

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess the impact of intrauterine infection on fetal brain damage by measuring S100B protein concentration in umbilical cord arteries.Methods: In the intrauterine infection cases determined by pathology of 25 deliveries (Group I) and non-infection cases of 35 deliveries as control (Group C), we compared gestational age at delivery, birth weight, fetal heart rate monitoring during labor, Apgar score, umbilical cord artery pH and S100B protein concentrations in umbilical arteries measured by two-site immunoradiometric assay kit.Results: (1) There was no significant correlation between pH and concentration of S100B protein. (2) Gestational age at delivery was found to be earlier in Group I, resulting in lower birth weights, when compared with Group C. (3) There was no significant difference between two groups concerning Apgar scores, pH. (4) S100B protein concentrations in Group I was significantly higher than those of Group C (3.9 70.66 versus 1.8 9 +/- 0.56g/L, p<0.05). (5) The concentration of S100B protein in severe chorioamnionitis (CAM) cases were significantly higher than those of mild CAM and control cases.Conclusion: Higher concentration of S100B protein in Group I suggests that intrauterine infection itself has a serious risk factor on fetal brain damage.

引用

页码：2463 / 2468

页数：6

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