Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS

被引：86

作者：

Hiraki, Tsubasa ^{[1
]}

Yoshimitsu, Makoto ^{[2
]}

Suzuki, Tadaki ^{[4
]}

Goto, Yuko ^{[1
]}

Higashi, Michiyo ^{[1
]}

Yokoyama, Seiya ^{[1
]}

Tabuchi, Tomohisa ^{[2
]}

Futatsuki, Takahiro ^{[3
]}

Nakamura, Kentaro ^{[3
]}

Hasegawa, Hideki ^{[4
]}

Saijo, Masayuki ^{[5
]}

Kakihana, Yasuyuki ^{[3
]}

Arima, Naomichi ^{[2
]}

Yonezawa, Suguru ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Oncol, Dept Human Pathol, Kagoshima 8908544, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Hematol & Immunol, Kagoshima 8908544, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Emergency & Intens Care Med, Kagoshima 8908544, Japan

[4] Natl Inst Infect Dis, Dept Pathol, Tokyo, Japan

[5] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

来源：

PATHOLOGY INTERNATIONAL | 2014年 / 64卷 / 11期

基金：

日本学术振兴会;

关键词：

autopsy cases; fungal infection; necrotizing lymphadenitis; SFTS virus-nucleoprotein antigen; SFTS; TO-PERSON TRANSMISSION; SYNDROME BUNYAVIRUS;

D O I：

10.1111/pin.12207

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.

引用

页码：569 / 575

页数：7

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