Bullous pemphigoid treated with leflunomide - A novel immunomodulatory agent

被引:18
作者
Nousari, HC [1 ]
Anhalt, GJ [1 ]
机构
[1] Johns Hopkins Med Inst, Div Dermatoimmunol, Baltimore, MD 21205 USA
关键词
D O I
10.1001/archderm.136.10.1204
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
引用
收藏
页码:1204 / 1205
页数:2
相关论文
共 16 条
[1]   The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase [J].
Davis, JP ;
Cain, GA ;
Pitts, WJ ;
Magolda, RL ;
Copeland, RA .
BIOCHEMISTRY, 1996, 35 (04) :1270-1273
[2]  
Fox RI, 1998, J RHEUMATOL, V25, P20
[3]   Inhibition of murine IgE and immediate cutaneous hypersensitivity responses to ovalbumin by the immunomodulatory agent leflunomide [J].
Jarman, ER ;
Kuba, A ;
Montermann, E ;
Bartlett, RR ;
Reske-Kunz, AB .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1999, 115 (02) :221-228
[4]   BLOOD DISTRIBUTION AND SINGLE-DOSE PHARMACOKINETICS OF LEFLUNOMIDE [J].
LUCIEN, J ;
DIAS, VC ;
LEGATT, DF ;
YATSCOFF, RW .
THERAPEUTIC DRUG MONITORING, 1995, 17 (05) :454-459
[5]  
Manna SK, 1999, J IMMUNOL, V162, P2095
[6]   Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine [J].
Nair, RV ;
Cao, W ;
Morris, RE .
IMMUNOLOGY LETTERS, 1995, 48 (02) :77-80
[7]   Pemphigus and bullous pemphigoid [J].
Nousari, HC ;
Anhalt, GJ .
LANCET, 1999, 354 (9179) :667-672
[8]  
NOUSARI HC, 1999, FITZPATRICKS DERMATO, P2853
[9]   Dihydroorotate dehydrogenase inhibitors: Quantitative structure-activity relationship analysis [J].
Ren, SJ ;
Wu, SK ;
Lien, EJ .
PHARMACEUTICAL RESEARCH, 1998, 15 (02) :286-295
[10]   Leflunomide inhibits pyrimidine de Novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans [J].
Rückemann, K ;
Fairbanks, LD ;
Carrey, EA ;
Hawrylowicz, CM ;
Richards, DF ;
Kirschbaum, B ;
Simmonds, HA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (34) :21682-21691