Expansion of monocytic myeloid-derived suppressor cells in endometriosis patients: A pilot study

被引：20
作者：
Chen, Haiwen [1 ,2 ]
Qin, Shuang [1 ]
Lei, Aihua [1 ,2 ]
Li, Xing [1 ,2 ]
Gao, Qi [1 ]
Dong, Jingyin [3 ]
Xiao, Qing [1 ]
Zhou, Jie [1 ,2 ,4 ]
机构：
[1] Zhongshan Sch Med, Affiliated Guangzhou Women & Childrens Med Ctr, Program Immunol, Guangzhou 510623, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Inst Human Virol, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China
[3] Zhejiang Univ City Coll, Hangzhou 310015, Zhejiang, Peoples R China
[4] Sun Yat Sen Univ, Chinese Minist Educ, Key Lab Trop Dis Control, Guangzhou 510080, Guangdong, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2017年 / 47卷
基金：
中国国家自然科学基金;
关键词：
Endometriosis; Monocytic myeloid-derived suppressor cells; Reactive oxygen species; T cells; REGULATORY T-CELLS; PERITONEAL-FLUID; AUTOIMMUNE-DISEASE; PERIPHERAL-BLOOD; HUMAN-PREGNANCY; PATHOGENESIS; RESPONSES; PROLIFERATION; DYSFUNCTION; ACTIVATION;
D O I：
10.1016/j.intimp.2017.03.026
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Endometriosis is a chronic inflammation disease and is closely associated with immune dysregulation. Myeloid derived suppressor cells (MDSCs) are a negative regulator of the immune system. The aim of this study was to evaluate the possible role of MDSCs in endometriosis patients. We collected the peripheral blood and peritoneal fluid from endometriosis patients and controls and analyzed M-MDSCs level using specific monoclonal antibodies recognizing HLA-DR, CD33, CD11b, CD14 markers by flow cytometry. We found that there existed abnormal expansion of monocytic MDSCs (M-MDSCs) (HLA-DR(-/low)CD33(+) CD11b(+) CD14(+)) in peripheral blood and peritoneal fluid of patients with endometriosis. Functional studies revealed that M-MDSCs from endometriosis patients significantly suppressed T-cell responses and produced high level of reactive oxygen species (ROS). The elevation of M-MDSCs from endometriosis patients may contribute to the disease progression. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：150 / 158
页数：9
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