Background/Aim: Hypersensitivity reactions (HSRs) to carboplatin, a key drug for ovarian cancer patients, are problematic. The aim of this study was to evaluate the efficacy and safety of readministration of platinum agents (PTs) in recurrent ovarian cancer patients who developed HSRs to carboplatin. Patients and Methods: Thirty-one patients with recurrent ovarian cancer who developed HSRs to carboplatin were divided into those who continued to receive PTs in the following cycle (continuation group, n=24) and those in whom either the drug was switched to non-platinum agents (non-PTs) or chemotherapy was ended (discontinuation group, n=7). Outcomes were evaluated based on patients' medical records. Results: The median survival time following HSRs was 28.1 and 15.4 months in the continuation and discontinuation groups, respectively (p=0.018). In the continuation group, a total of 155 cycles of PTs were re-administrated, and 50 cycles (32%) led to recurrent HSRs. There were no recurrent HSRs with a severity of grade 3 or greater. Conclusion: Continuation of PTs in ovarian cancer patients may contribute to improvement in their overall survival without severe recurrent HSRs.
机构:
Stanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USAStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Berek, Jonathan S.
;
Kehoe, Sean T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Inst Canc & Genom, Birmingham, W Midlands, EnglandStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Kehoe, Sean T.
;
Kumar, Lalit
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Med Oncol, New Delhi, IndiaStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Kumar, Lalit
;
Friedlander, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Women, Sydney, NSW, Australia
Univ New South Wales, Clin Sch, Sydney, NSW, AustraliaStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Dizon, DS
;
Sabbatini, PJ
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Sabbatini, PJ
;
Aghajanian, C
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Aghajanian, C
;
Hensley, ML
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Hensley, ML
;
Spriggs, DR
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Koshiba, H.
;
Hosokawa, K.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Hosokawa, K.
;
Kubo, A.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Pharmaceut Univ, Dept Hosp Pharmacol, Yamashina Ku, Kyoto 607, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Kubo, A.
;
Miyagi, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, Japan
Shizuoka Canc Ctr Hosp, Med Examinat Ctr, Nagaizumi, Shizuoka, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Miyagi, Y.
;
Oda, T.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Oda, T.
;
Miyagi, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, Japan
Shizuoka Canc Ctr Hosp, Med Examinat Ctr, Nagaizumi, Shizuoka, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Miyagi, Y.
;
Watanabe, A.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Watanabe, A.
;
Honjo, H.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
Lax, Timothy
;
Long, Aidan
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
Long, Aidan
;
Banerji, Aleena
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
机构:
Stanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USAStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Berek, Jonathan S.
;
Kehoe, Sean T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Inst Canc & Genom, Birmingham, W Midlands, EnglandStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Kehoe, Sean T.
;
Kumar, Lalit
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Med Oncol, New Delhi, IndiaStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
Kumar, Lalit
;
Friedlander, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Women, Sydney, NSW, Australia
Univ New South Wales, Clin Sch, Sydney, NSW, AustraliaStanford Univ, Sch Med, Stanford Canc Inst, Stanford Womens Canc Ctr, Stanford, CA 94305 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Dizon, DS
;
Sabbatini, PJ
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Sabbatini, PJ
;
Aghajanian, C
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Aghajanian, C
;
Hensley, ML
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
Hensley, ML
;
Spriggs, DR
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, Dev Chemotherapy Serv, New York, NY 10021 USA
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Koshiba, H.
;
Hosokawa, K.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Hosokawa, K.
;
Kubo, A.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Pharmaceut Univ, Dept Hosp Pharmacol, Yamashina Ku, Kyoto 607, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Kubo, A.
;
Miyagi, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, Japan
Shizuoka Canc Ctr Hosp, Med Examinat Ctr, Nagaizumi, Shizuoka, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Miyagi, Y.
;
Oda, T.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Oda, T.
;
Miyagi, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Ohfuku Clin, Okayama, Japan
Shizuoka Canc Ctr Hosp, Med Examinat Ctr, Nagaizumi, Shizuoka, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Miyagi, Y.
;
Watanabe, A.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
Watanabe, A.
;
Honjo, H.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med, Dept Obstet & Gynecol, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
Lax, Timothy
;
Long, Aidan
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
Long, Aidan
;
Banerji, Aleena
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA