The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

被引：220

作者：

Gillespie, KM

Bain, SC

Barnett, AH

Bingley, PJ

Christie, MR

Gill, GV

Gale, EAM

机构：

[1] Univ Bristol, Diabet & Metab Div Med, Bristol, Avon, England

[2] Univ Birmingham, Birmingham, W Midlands, England

[3] Birmingham Heartlands & Solihull NHS Trust, Birmingham, W Midlands, England

[4] Univ Liverpool, Univ Hosp Aintree, Dept Med, Liverpool L69 3BX, Merseyside, England

[5] Guys Kings & St Thomas Sch Med, Dept Med, London, England

来源：

LANCET | 2004年 / 364卷 / 9446期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(04)17357-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0.003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.

引用

页码：1699 / 1700

页数：2

共 7 条

[1] Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort) [J].

Bain, SC ;

Gill, GV ;

Dyer, PH ;

Jones, AF ;

Murphy, M ;

Jones, KE ;

Smyth, C ;

Barnett, AH .

DIABETIC MEDICINE, 2003, 20 (10) :808-811

[2] Human leucocyte antigen and insulin gene regions and nephropathy in Type I diabetes [J].

Chowdhury, TA ;

Dyer, PH ;

Mijovic, CH ;

Dunger, DB ;

Barnett, AH ;

Bain, SC .

DIABETOLOGIA, 1999, 42 (08) :1017-1020

[3]

FALCONER DS, 1964, INTRO QUANTITATIVE G, P301

[4] The rise of childhood type 1 diabetes in the 20th century [J].

Gale, EAM .

DIABETES, 2002, 51 (12) :3353-3361

[5] Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis [J].

Gardner, SG ;

Bingley, PJ ;

Sawtell, PA ;

Weeks, S ;

Gale, EAM ;

Bell, RAF ;

Dunger, DB ;

Mukhtar, A ;

OMalley, BP ;

Silk, BR ;

Smith, EH ;

Scott, RDM ;

Latham, PJ ;

Lakhani, PK ;

Paton, RC ;

Ackland, FM ;

Fox, CJ ;

Griffin, NK ;

Matthews, DR ;

Neil, HAW ;

Mann, NP ;

Simpson, HCR ;

Brown, RS ;

Knight, AH ;

Cowen, JM ;

Pearce, JC ;

Cheetham, CH ;

Gallen, IW ;

Sandler, L ;

Westcott, T .

BRITISH MEDICAL JOURNAL, 1997, 315 (7110) :713-717

[6] HLA class II typing of whole genome amplified mouth swab DNA [J].

Gillespie, KM ;

Valovin, SJ ;

Saunby, J ;

Hunter, KM ;

Savage, DA ;

Middleton, D ;

Todd, JA ;

Bingley, PJ ;

Gale, EAM .

TISSUE ANTIGENS, 2000, 56 (06) :530-538

[7] Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes -: indication of an increased environmental pressure? [J].

Hermann, R ;

Knip, M ;

Veijola, R ;

Simell, O ;

Laine, AP ;

Åkerblom, HK ;

Groop, PH ;

Forsblom, C ;

Pettersson-Fernholm, K ;

Ilonen, J .

DIABETOLOGIA, 2003, 46 (03) :420-425

← 1 →