Allogeneic double-negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first-in-human phase I study

被引：18

作者：

Tang, Baolin ^{[1
,2
,3
]}

Lee, Jong Bok ^{[4
,5
,6
]}

Cheng, Siqi ^{[7
]}

Pan, Tianzhong ^{[1
,2
,3
]}

Yao, Wen ^{[1
]}

Wang, Dongyao ^{[1
]}

Tu, Meijuan ^{[1
]}

Xiang, Zhiqiang ^{[8
,9
]}

Chu, Xiandeng ^{[10
]}

Geng, Liangquan ^{[1
]}

Qiang, Ping ^{[1
]}

Teng, Pingping ^{[8
,9
]}

Sun, Guangyu ^{[1
]}

Liu, Huilan ^{[1
,2
,3
]}

Wang, Jian ^{[1
]}

Schimmer, Aaron D. ^{[11
]}

Yang, Liming ^{[8
,9
]}

Sun, Zimin ^{[1
,2
,3
]}

Zhang, Li ^{[4
,5
,6
]}

Zhu, Xiaoyu ^{[1
,2
,3
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hematol, Div Life Sci & Med, Hefei 230001, Peoples R China

[2] Univ Sci & Technol China, Blood & Cell Therapy Inst, Div Life Sci & Med, Hefei, Peoples R China

[3] Anhui Prov Key Lab Blood Res & Applict, Hefei, Peoples R China

[4] Univ Hlth Network, Toronto Gen Hosp Res Inst, Transplantat Dept, Toronto, ON, Canada

[5] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[6] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[7] Huaibei Peoples Hosp, Dept Hematol, Huaibei, Peoples R China

[8] WYZE Biotech Co Ltd, R&D Ctr, Hangzhou, Peoples R China

[9] Ruichuang Biotechnol Co Ltd, Cell Mfg Dept, Shaoxing, Peoples R China

[10] Anhui Med Univ, Dept Hematol, Luan Hosp, Luan, Peoples R China

[11] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2022年 / 97卷 / 07期

关键词：

D O I：

10.1002/ajh.26564

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E264 / E267

页数：4

共 6 条

[1] Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib [J].

Kang, Hyeonjeong ;

Lee, Jong Bok ;

Khatri, Ismat ;

Na, Yoosu ;

D'Souza, Cheryl ;

Arruda, Andrea ;

Minden, Mark D. ;

Zhang, Li .

CANCERS, 2021, 13 (20)

[2] Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer [J].

Lee, Jong Bok ;

Kang, Hyeonjeong ;

Fang, Linan ;

D'Souza, Cheryl ;

Adeyi, Oyedele ;

Zhang, Li .

CLINICAL CANCER RESEARCH, 2019, 25 (07) :2241-2253

[3] Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms [J].

Lee, JongBok ;

Minden, Mark D. ;

Chen, Weihsu C. ;

Streck, Elena ;

Chen, Branson ;

Kang, Hyeonjeong ;

Arruda, Andrea ;

Ly, Dalam ;

Der, Sandy D. ;

Kang, Sohyeong ;

Achita, Paulina ;

D'Souza, Cheryl ;

Li, Yueyang ;

Childs, Richard W. ;

Dick, John E. ;

Zhang, Li .

CLINICAL CANCER RESEARCH, 2018, 24 (02) :370-382

[4] Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial [J].

Platzbecker, Uwe ;

Middeke, Jan Moritz ;

Sockel, Katja ;

Herbst, Regina ;

Wolf, Dominik ;

Baldus, Claudia D. ;

Oelschlagel, Uta ;

Mutherig, Anke ;

Fransecky, Lars ;

Noppeney, Richard ;

Bug, Gesine ;

Goetze, Katharina S. ;

Kraemer, Alwin ;

Bochtler, Tilmann ;

Stelljes, Matthias ;

Groth, Christoph ;

Schubert, Antje ;

Mende, Marika ;

Stoelzel, Friedrich ;

Borkmann, Christin ;

Kubasch, Anne Sophie ;

von Bonin, Malte ;

Serve, Hubert ;

Haenel, Mathias ;

Duehrsen, Ulrich ;

Schetelig, Johannes ;

Roellig, Christoph ;

Kramer, Michael ;

Ehninger, Gerhard ;

Bornhaeuser, Martin ;

Thiede, Christian .

LANCET ONCOLOGY, 2018, 19 (12) :1668-1679

[5] Relapse of AML after hematopoietic stem cell transplantation: methods of monitoring and preventive strategies. A review from the ALWP of the EBMT [J].

Tsirigotis, P. ;

Byrne, M. ;

Schmid, C. ;

Baron, F. ;

Ciceri, F. ;

Esteve, J. ;

Gorin, N. C. ;

Giebel, S. ;

Mohty, M. ;

Savani, B. N. ;

Nagler, A. .

BONE MARROW TRANSPLANTATION, 2016, 51 (11) :1431-1438

[6] Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes [J].

Yanada, Masamitsu ;

Konuma, Takaaki ;

Yamasaki, Satoshi ;

Kondo, Tadakazu ;

Fukuda, Takahiro ;

Shingai, Naoki ;

Sawa, Masashi ;

Ozawa, Yukiyasu ;

Tanaka, Masatsugu ;

Uchida, Naoyuki ;

Nakamae, Hirohisa ;

Katayama, Yuta ;

Matsuoka, Ken-ichi ;

Kimura, Takafumi ;

Kanda, Yoshinobu ;

Ichinohe, Tatsuo ;

Atsuta, Yoshiko ;

Yano, Shingo .

BONE MARROW TRANSPLANTATION, 2021, 56 (05) :1126-1133

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