Diversity Synthesis of N-Substituted 2-Amino-1,6-naphthyridine Derivatives under Microwave Irradiation

被引：28

作者：

Han, Zheng-Guo ^{[1
]}

Miao, Chun-Bao ^{[2
]}

Shi, Feng ^{[1
]}

Ma, Ning ^{[1
]}

Zhang, Ge ^{[1
]}

Tu, Shu-Jiang ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Jiangsu Polytech Univ, Sch Chem & Chem Engn, Changzhou 213164, Jiangsu, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 01期

基金：

美国国家科学基金会;

关键词：

TRANSFORMATIONS; EFFICIENT; CHEMISTRY;

D O I：

10.1021/cc900030e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH4OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.

引用

页码：16 / 19

页数：4

共 26 条

[1]

Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO

[2]

2-A

[3]

Blagg J., Patent WO, Patent No. 2003076427

[4]

Bose AK, 1997, CHEMTECH, V27, P18

[5] MICROWAVE-ASSISTED ORGANIC-REACTIONS [J].

CADDICK, S .

TETRAHEDRON, 1995, 51 (38) :10403-10432

[6]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[7]

2-U

[8] Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure-affinity investigation [J].

Dukat, M ;

Fiedler, W ;

Dumas, D ;

Damaj, I ;

Martin, BR ;

Rosecrans, JA ;

James, JR ;

Glennon, RA .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (11) :875-888

[9]

ELKASHEF HS, 1993, J CHEM TECHNOL BIOT, V57, P15

[10] Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates [J].

Gangjee, A ;

Zeng, YB ;

McGuire, JJ ;

Kisliuk, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (23) :5173-5181

← 1 2 3 →