Diversity Synthesis of N-Substituted 2-Amino-1,6-naphthyridine Derivatives under Microwave Irradiation

被引：28

作者：

Han, Zheng-Guo ^{[1
]}

Miao, Chun-Bao ^{[2
]}

Shi, Feng ^{[1
]}

Ma, Ning ^{[1
]}

Zhang, Ge ^{[1
]}

Tu, Shu-Jiang ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Jiangsu Polytech Univ, Sch Chem & Chem Engn, Changzhou 213164, Jiangsu, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 01期

基金：

美国国家科学基金会;

关键词：

TRANSFORMATIONS; EFFICIENT; CHEMISTRY;

D O I：

10.1021/cc900030e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH4OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.

引用

页码：16 / 19

页数：4

共 26 条

[1] Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO
[2] 2-A
[3] Blagg J., Patent WO, Patent No. 2003076427
[4] Bose AK, 1997, CHEMTECH, V27, P18
[5] MICROWAVE-ASSISTED ORGANIC-REACTIONS
CADDICK, S
[J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
[6] Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO
[7] 2-U
[8] Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure-affinity investigation
Dukat, M
Fiedler, W
Dumas, D
Damaj, I
Martin, BR
Rosecrans, JA
James, JR
Glennon, RA
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (11) : 875 - 888
[9] ELKASHEF HS, 1993, J CHEM TECHNOL BIOT, V57, P15
[10] Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates
Gangjee, A
Zeng, YB
McGuire, JJ
Kisliuk, RL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (23) : 5173 - 5181

← 1 2 3 →