Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats

被引：11

作者：

Parenti, Carmela ^{[1
]}

Arico, Giuseppina ^{[2
]}

Pennisi, Marzio ^{[3
]}

Venditti, Alessandro ^{[4
,5
]}

Scoto, Giovanna M. ^{[1
]}

机构：

[1] Univ Catania, Dept Drug Sci, Pharmacol & Toxicol Sect, Viale A Doria 6, I-95125 Catania, Italy

[2] Univ Catania, Dept Drug Sci, Med Chem Sect, Viale A Doria 6, I-95125 Catania, Italy

[3] Univ Catania, Dept Math & Comp Sci, Viale A Doria 6, I-95125 Catania, Italy

[4] Univ Roma La Sapienza, Dept Chem, Ple A Moro 5, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, Dept Environm Biol, Ple A Moro 5, I-00185 Rome, Italy

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 11期

关键词：

hyperalgesia; allodynia; synergism; opioid; persistent pain; Harpagophytum procumbens; INDUCED COX-2 EXPRESSION; DEVILS CLAW; TNF-ALPHA; PAIN; INHIBITION; HARPAGOSIDE; MECHANISMS; DC; HYPERALGESIA; ACTIVATION;

D O I：

10.1080/14786419.2015.1052069

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The association of opioids and non-steroidal anti-inflammatory drugs, to enhance pain relief and reduce the development of side effects, has been demonstrated. Given many reports concerning the antinociceptive and anti-inflammatory effects of Harpagophytum procumbens extracts, the aim of our study was to investigate the advantage of a co-administration of a subanalgesic dose of morphine preceded by a low dose of H. procumbens to verify this therapeutically useful association in a neuropathic pain model. Time course, registered with the association of the natural extract, at a dose that does not induce an antinociceptive effect, followed by a subanalgesic dose of morphine showed a well-defined antiallodynic and antihyperalgesic effect, suggesting a synergism as a result of the two-drug association. H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia, two typical symptoms of neuropathic pain. The results support the strategy of using an adjuvant drug to improve opioid analgesic efficacy.

引用

页码：1248 / 1255

页数：8

共 39 条

[31] Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats [J].

Redondo-Castro, Elena ;

Navarro, Xavier .

EXPERIMENTAL NEUROLOGY, 2014, 252 :95-103

[32]

Romero-Sandoval EA, 2008, CURR OPIN INVEST DR, V9, P726

[33] Models and Mechanisms of Hyperalgesia and Allodynia [J].

Sandkuehler, Juergen .

PHYSIOLOGICAL REVIEWS, 2009, 89 (02) :707-758

[34] Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: Implications for the anti-tumor-promoter effect of vegetables [J].

Sawa, T ;

Nakao, M ;

Akaike, T ;

Ono, K ;

Maeda, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (02) :397-402

[35] Harpagophytum procumbens Prevents Oxidative Stress and Loss of Cell Viability In Vitro [J].

Schaffer, Larissa Finger ;

Peroza, Luis Ricardo ;

Boligon, Aline Augusti ;

Athayde, Margareth Linde ;

Alves, Sydney Hartz ;

Fachinetto, Roselei ;

Wagner, Caroline .

NEUROCHEMICAL RESEARCH, 2013, 38 (11) :2256-2267

[36] Antinociceptive effects of St. John's wort, Haipagophytum procumbens extract and grape seed proanthocyanidins extract in mice [J].

Uchida, Shinya ;

Hirai, Keita ;

Hatanaka, Junya ;

Hanato, Junko ;

Umegaki, Keizo ;

Yamada, Shizuo .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (02) :240-245

[37]

Volk OH, 1953, COMPLETE GERMAN COMM, P249

[38] Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs [J].

Zelcer, S ;

Kolesnikov, Y ;

Kovalyshyn, I ;

Pasternak, DA ;

Pasternak, GW .

BRAIN RESEARCH, 2005, 1040 (1-2) :151-156

[39]

Zorn B, 1958, PRELIMINARY REPORT, V17, P134

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