PEGylation of Chitosan Via Nitroxide-Mediated Polymerization in Aqueous Media

被引：20

作者：

Darabi, Ali ^{[1
]}

Garcia-Valdez, Omar ^{[1
]}

Champagne, Pascale ^{[2
]}

Cunningham, Michael F. ^{[1
]}

机构：

[1] Queens Univ, Dept Chem Engn, 19 Div St, Kingston, ON K7L 3N6, Canada

[2] Queens Univ, Dept Civil Engn, 58 Univ Ave, Kingston, ON K7M, Canada

来源：

MACROMOLECULAR REACTION ENGINEERING | 2016年 / 10卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

chitosan; nitroxide-mediatedpolymerization; PEGylation; RADICAL POLYMERIZATION; POLY(ETHYLENE GLYCOL); METHYL-METHACRYLATE; AMINO-GROUPS; SIDE-CHAINS; POLYMETHACRYLATES; POLYSTYRENICS; POSITION; STYRENE;

D O I：

10.1002/mren.201500024

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The PEGlytation of CTS with poly(poly(ethyleneglycol) methyl ether methacrylate-co-styrene), poly(PEGMA-co-S), via nitroxide-mediated polymerization (NMP) using both grafting to and from approaches has been performed. To conduct the PEGylation of CTS via grafting to, CTS was first functionalized with glycidyl methacrylate (GMA) yielding CTS-g-GMA macromer. Poly(PEGMA-co-S), synthesized via NMP, was then grafted to the CTS-g-GMA. For PEGylation via grafting from, CTS-g-GMA was first converted into a macroalkoxyamine using an SG1-based alkoxyamine. Graft copolymerization of PEGMA-co-S was then performed. The syntheses of CTS-g-GMA-poly(PEGMA-co-S) were confirmed by H-1 NMR and TGA.

引用

页码：82 / 89

页数：8

共 33 条

[1] A Facile Route for Regioselective Conjugation of Organo-Soluble Polymers onto Chitosan
Cai, Guoqiang
Jiang, Hongliang
Tu, Kehua
Wang, Liqun
Zhu, Kangjie
[J]. MACROMOLECULAR BIOSCIENCE, 2009, 9 (03) : 256 - 261
[2] PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications
Casettari, Luca
Vllasaliu, Driton
Castagnino, Enzo
Stolnik, Snjezana
Howdle, Steven
Illum, Lisbeth
[J]. PROGRESS IN POLYMER SCIENCE, 2012, 37 (05) : 659 - 685
[3] Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions
Chenal, Marion
Mura, Simona
Marchal, Cathie
Gigmes, Didier
Charleux, Bernadette
Fattal, Elias
Couvreur, Patrick
Nicolas, Julien
[J]. MACROMOLECULES, 2010, 43 (22) : 9291 - 9303
[4] Deng LD, 2007, J BIOMAT SCI-POLYM E, V18, P1575
[5] PEGylation of chitosan for improved solubility and fiber formation via electrospinning
Du, Jian
Hsieh, You-Lo
[J]. CELLULOSE, 2007, 14 (06) : 543 - 552
[6] Synthesis and characterization of chitosan-g-glycidyl methacrylate with methyl methacrylate
Elizalde-Pena, E. A.
Flores-Ramirez, N.
Luna-Barcenas, G.
Vasquez-Garcia, S. R.
Arambula-Villa, G.
Garcia-Gaitan, B.
Rutiaga-Quinones, J. G.
Gonzalez-Hernandez, J.
[J]. EUROPEAN POLYMER JOURNAL, 2007, 43 (09) : 3963 - 3969
[7] Characterization and degradation of functionalized chitosan with glycidyl methacrylate
Flores-Ramírez, N
Elizalde-Peña, EA
Vásquez-García, SR
González-Hernández, J
Martinez-Ruvalcaba, A
Sanchez, IC
Luna-Bárcenas, G
Gupta, RB
[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2005, 16 (04) : 473 - 488
[8] Modification of chitosan with polystyrene and poly(n-butyl acrylate) via nitroxide-mediated polymerization and grafting from approach in homogeneous media
Garcia-Valdez, O.
Champagne-Hartley, R.
Saldivar-Guerra, E.
Champagne, P.
Cunningham, M. F.
[J]. POLYMER CHEMISTRY, 2015, 6 (15) : 2827 - 2836
[9] Grafting of Chitosan with Styrene and Maleic Anhydride via Nitroxide-Mediated Radical Polymerization in Supercritical Carbon Dioxide
Garcia-Valdez, Omar
Guadalupe Ramirez-Wong, Diana
Saldivar-Guerra, Enrique
Luna-Barcenas, Gabriel
[J]. MACROMOLECULAR CHEMISTRY AND PHYSICS, 2013, 214 (12) : 1396 - 1404
[10] Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers
Gorochovceva, N
Makuska, R
[J]. EUROPEAN POLYMER JOURNAL, 2004, 40 (04) : 685 - 691

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