Natural Products as Chemical Probes

被引：174

作者：

Carlson, Erin E. ^{[1
,2
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] Indiana Univ, Dept Mol & Cellular Biochem, Bloomington, IN 47405 USA

来源：

ACS CHEMICAL BIOLOGY | 2010年 / 5卷 / 07期

关键词：

NERVE GROWTH-FACTOR; EUKARYOTIC TRANSLATION INITIATION; DELTA-AMINO-TRANSFERASE; MAMMALIAN TARGET; SMALL MOLECULES; ATPASE ACTIVITY; FELLUTAMIDE-B; DIAZONAMIDE-A; IDENTIFICATION; RAPAMYCIN;

D O I：

10.1021/cb100105c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products have evolved to encompass a broad spectrum of chemical and functional diversity. It is this diversity, along with their structural complexity, that enables nature's small molecules to target a nearly limitless number of biological macromolecules and to often do so in a highly selective fashion. Because of these characteristics, natural products have seen great success as therapeutic agents. However, this vast pool of compounds holds much promise beyond the development of future drugs. These features also make them ideal tools for the study of biological systems. Recent examples of the use of natural products and their derivatives as chemical probes to explore biological phenomena and assemble biochemical pathways are presented here.

引用

页码：639 / 653

页数：15

共 103 条

[11] Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation [J].

Bordeleau, ME ;

Matthews, J ;

Wojnar, JM ;

Lindqvist, L ;

Novac, O ;

Jankowsky, E ;

Sonenberg, N ;

Northcote, P ;

Teesdale-Spittlet, P ;

Pelletier, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10460-10465

[12]

BRODY LC, 1992, J BIOL CHEM, V267, P3302

[13] A proteomics approach to discovering natural products and their biosynthetic pathways [J].

Bumpus, Stefanie B. ;

Evans, Bradley S. ;

Thomas, Paul M. ;

Ntai, Ioanna ;

Kelleher, Neil L. .

NATURE BIOTECHNOLOGY, 2009, 27 (10) :951-U120

[14] Target identification in chemical genetics: The (often) missing link [J].

Burdine, L ;

Kodadek, T .

CHEMISTRY & BIOLOGY, 2004, 11 (05) :593-597

[15]

BUTT MS, CRIT REV FOOD SCI NU, V49, P463

[16] Nerve growth factor: Possibilities and limitations of its clinical application [J].

Castellanos-Ortega, R ;

Cruz-Aguado, R ;

Martinez-Marti, L .

REVISTA DE NEUROLOGIA, 1999, 29 (05) :439-447

[17] High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK [J].

Chang, Lyra ;

Bertelsen, Eric B. ;

Wisen, Susanne ;

Larsen, Erik M. ;

Zuiderweg, Erik R. P. ;

Gestwicki, Jason E. .

ANALYTICAL BIOCHEMISTRY, 2008, 372 (02) :167-176

[18] IDENTIFICATION AND CHARACTERIZATION OF MOLECULAR TARGETS OF NATURAL PRODUCTS BY MASS SPECTROMETRY [J].

Cheng, Ka-Wing ;

Wong, Chi-Chun ;

Wang, Mingfu ;

He, Qing-Yu ;

Chen, Feng .

MASS SPECTROMETRY REVIEWS, 2010, 29 (01) :126-155

[19] Lessons from natural molecules [J].

Clardy, J ;

Walsh, C .

NATURE, 2004, 432 (7019) :829-837

[20] Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One [J].

Corson, Timothy W. ;

Aberle, Nicholas ;

Crews, Craig M. .

ACS CHEMICAL BIOLOGY, 2008, 3 (11) :677-692

← 1 2 3 4 5 6 7 8 9 10 →