Antitumor activity of novel reversible LSD1 inhibitors in preclinical models of AML and SCLC.

被引:0
|
作者
Byun, Joo-Yun [1 ]
Lee, Won Jong [1 ]
Kim, Won jung [1 ]
Kim, Minjeong [1 ]
Bae, Inhwan [1 ]
Hong, Seokhyun [1 ]
Kim, Yu-Yon [1 ]
Park, Hyunjin [1 ]
Kim, Eunyoung [1 ]
Kim, Young Hoon [1 ]
Ahn, Young Gil [1 ]
Suh, Kwee Hyun [1 ]
机构
[1] Hanmi Res Ctr, Hwaseong Si, South Korea
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1135
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Antitumor activity of novel reversible LSD1 inhibitor in preclinical models of AML and SCLC
    Bae, InHwan
    Kim, WonJeoun
    Kim, JiSook
    Song, JiYoung
    Nam, JungSoo
    Lee, Moonsub
    Byun, Jooyun
    Kim, Hyeongki
    Song, TaeHun
    Hong, Seokhyun
    Lee, KyuHang
    Ahn, YoungGil
    Kim, YoungHoon
    Suh, Kwee Hyun
    CANCER RESEARCH, 2019, 79 (13)
  • [2] Antitumor activity of novel reversible LSD1 inhibitor, HM97211 in preclinical models of SCLC
    Bae, InHwan
    Kim, JiSook
    Park, ChangHee
    Kim, Hyeongki
    Gwangmog, Namgoong
    Byun, Joo-Yun
    Hong, Seokhyun
    Song, Teahun
    Lee, Jaeho
    Lee, Kyuhang
    Ko, Myoungsil
    Kim, Cheolkyung
    Lee, YoungMi
    Lee, Ho Jeong
    Kim, YoungHoon
    Ahn, YoungGil
    Suh, KweeHyun
    Kim, Sun-Jin
    CANCER RESEARCH, 2018, 78 (13)
  • [3] A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 inhibitors in SCLC
    Mohammad, Helai P.
    Smitheman, Kimberly N.
    Kamat, Chandrashekhar D.
    Soong, David
    Federowicz, Kelly E.
    Van Aller, Glenn S.
    Schneck, Jess L.
    Carson, Jeffrey D.
    Liu, Yan
    Butticello, Michael
    Bonnette, William G.
    Gorman, Shelby A.
    Degenhardt, Yan
    Bai, Yuchen
    McCabe, Michael T.
    Pappalardi, Melissa B.
    Kasparec, Jiri
    Tian, Xinrong
    McNulty, Kenneth C.
    Rouse, Meagan
    McDevitt, Patrick
    Ho, Thau
    Crouthamel, Michelle
    Hart, Timothy K.
    Concha, Nestor O.
    McHugh, Charles F.
    Miller, William H.
    Dhanak, Dashyant
    Tummino, Peter J.
    Carpenter, Christopher L.
    Johnson, Neil W.
    Hann, Christine L.
    Kruger, Ryan G.
    CANCER CELL, 2015, 28 (01) : 57 - 69
  • [4] A DNA hypomethylation signature predicts novel antitumor activity of LSD1 inhibition in SCLC
    Mohammad, Helai
    Kruger, Ryan
    CANCER RESEARCH, 2016, 76
  • [5] TPC-144, a novel reversible LSDI inhibitor, exhibited strong antitumor activity in preclinical models of AML and SCLC
    Kawagishi, A.
    Yamashita, S.
    Hatanaka, R.
    Kodama, Y.
    Tsuji, S.
    Ogawa, T.
    Osada, A.
    Tanaka, K.
    Komatani, H.
    Matsuo, K.
    Utsugi, T.
    Iwasawa, Y.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S86 - S87
  • [6] Antitumor activity of LSD1 inhibitors in lung cancer
    Mohammad, Helai P.
    Kruger, Ryan G.
    MOLECULAR & CELLULAR ONCOLOGY, 2016, 3 (02)
  • [7] Combination of TPC-144, a reversible LSD1 inhibitor, and a hypomethylating agent resulted in synergistic antitumor efficacy in preclinical models of AML
    Osada, Akiko
    Kawagishi, Aki
    Hatanaka, Ryo
    Machida, Takumitsu
    Ito, Kenjiro
    Yamashita, Satoshi
    Ogawa, Takahiro
    Imaoka, Tadashi
    Matsuo, Kenichi
    Utsugi, Teruhiro
    Iwasawa, Yoshikazu
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [8] Discovery of reversible LSD1 inhibitors
    Kanouni, Toufike
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [9] Discovery of potent reversible inhibitors of LSD1
    Chen, Young
    Kanouni, Toufike
    Severin, Christophe
    Xu, Jiangchun
    Del Rosario, Joselyn
    Shi, Lihong
    Lai, Chon
    Stafford, Jeffrey
    Veal, Jim
    Stansfield, Ryan
    Cho, Rob
    Yuen, Natalie
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [10] Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
    Yang, Jie
    Talibov, Vladimir O.
    Peintner, Stefan
    Rhee, Claire
    Poongavanam, Vasanthanathan
    Geitmann, Matthis
    Sebastiano, Matteo Rossi
    Simon, Bernd
    Hennig, Janosch
    Dobritzsch, Doreen
    Danielson, U. Helena
    Kihlberg, Jan
    ACS OMEGA, 2020, 5 (08): : 3979 - 3995