Triterpenes as Potentially Cytotoxic Compounds

被引：124
作者：
Chudzik, Malwina [1 ]
Korzonek-Szlacheta, Ilona [2 ]
Krol, Wojciech [1 ]
机构：
[1] Med Univ Silesia, Chair & Dept Microbiol & Immunol, PL-41808 Zabrze, Poland
[2] Med Univ Silesia, Fac Publ Hlth, Dept Nutr Associated Dis Prevent, PL-41902 Bytom, Poland
来源：
MOLECULES | 2015年 / 20卷 / 01期
关键词：
triterpenes; cytotoxicity; URSOLIC ACID-DERIVATIVES; BETULINIC ACID; OLEANOLIC ACID; PENTACYCLIC TRITERPENES; LANOSTANE TRITERPENOIDS; ANTITUMOR ACTIVITIES; COLORIMETRIC ASSAYS; CANCER CELLS; IN-VITRO; SAPONINS;
D O I：
10.3390/molecules20011610
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Triterpenes are compounds of natural origin, which have numerously biological activities: anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti-fungal. These substances can be isolated from plants, animals or fungi. Nowadays, when neoplasms are main cause of death, triterpenes can become an alternative method for treating cancer because of their cytotoxic properties and chemopreventive activities.
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收藏
页码：1610 / 1625
页数：16
相关论文
共 97 条
  • [1] Anticancer Activity of 3-O-Acylated Betulinic Acid Derivatives Obtained by Enzymatic Synthesis
    Ahmad, Faujan Bin H.
    Moghaddam, Mansour Ghaffari
    Basri, Mahiran
    Rahman, Mohd Basyaruddin Abdul
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2010, 74 (05) : 1025 - 1029
  • [2] Antimicrobial and cytotoxic constituents from leaves of Sapium baccatum
    Ahmed, Yunus
    Sohrab, Md. Hossain
    Al-Reza, Sharif M.
    Tareq, Faqir Shahidulla
    Hasan, Choudhury M.
    Sattar, M. A.
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (02) : 549 - 552
  • [3] Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
    Bai, Kai-Kai
    Yu, Zhou
    Chen, Fen-Ling
    Li, Feng
    Li, Wei-Yun
    Guo, Yang-Hao
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (07) : 2488 - 2493
  • [4] Lupane triterpenes and derivatives with antiviral activity
    Baltina, LA
    Flekhter, OB
    Nigmatullina, LR
    Boreko, EI
    Pavlova, NI
    Nikolaeva, SN
    Savinova, OV
    Tolstikova, GA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (20) : 3549 - 3552
  • [5] Baniadam S, 2014, IRAN J PHARM RES, V13, P135
  • [6] Preparation of betulinic acid derivatives by chemical and biotransformation methods and determination of cytotoxicity against selected cancer cell lines
    Baratto, Leopoldo C.
    Porsani, Mariana V.
    Pimentel, Ida C.
    Pereira Netto, Adaucto B.
    Paschke, Reinhard
    Oliveira, Bras H.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 68 : 121 - 131
  • [7] Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    Bishayee, Anupam
    Ahmed, Shamima
    Brankov, Nikoleta
    Perloff, Marjorie
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 : 980 - 996
  • [8] Bopp Stephanie K., 2008, BMC Pharmacology, V8, P8, DOI 10.1186/1471-2210-8-8
  • [9] Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
    Boryczka, Stanislaw
    Bebenek, Ewa
    Wietrzyk, Joanna
    Kempinska, Katarzyna
    Jastrzebska, Maria
    Kusz, Joachim
    Nowak, Maria
    [J]. MOLECULES, 2013, 18 (04): : 4526 - 4543
  • [10] Breitmaier E., 2006, Terpenes: flavors, fragrances, pharmaca, pheromones
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