Role of vitamin D pathway gene polymorphisms on rifampicin plasma and intracellular pharmacokinetics

被引：12

作者：

Allegra, Sarah ^{[1
]}

Fatiguso, Giovanna ^{[1
]}

Calcagno, Andrea ^{[1
]}

Baietto, Lorena ^{[1
]}

Motta, Ilaria ^{[1
]}

Favata, Fabio ^{[1
]}

Cusato, Jessica ^{[1
]}

Bonora, Stefano ^{[1
]}

Di Perri, Giovanni ^{[1
]}

D'Avolio, Antonio ^{[1
]}

机构：

[1] Univ Turin, Unit Infect Dis, Lab Clin Pharmacol & Pharmacogenet, Amedeo Savoia Hosp,Dept Med Sci, Corso Svizzera 164, I-10149 Turin, Italy

来源：

PHARMACOGENOMICS | 2017年 / 18卷 / 09期

关键词：

ABCB1; Cdx2; CYP24A1; FokI; pharmacokinetics; TaqI; tuberculosis; D-RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISMS; SLCO1B1; POLYMORPHISM; MDR1; GENE; MYCOBACTERIUM-TUBERCULOSIS; 1,25-DIHYDROXYVITAMIN D-3; IMMUNE-SYSTEM; CUTTING EDGE; EXPRESSION; DRUG;

D O I：

10.2217/pgs-2017-0176

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We retrospectively evaluate the pharmacogenetic role of single nucleotide polymorphisms involved in rifampicin transport (SLCO1B1, MDR1 and PXR genes) and vitamin D (VDR, CYP24A1 and CYP27B1 genes) metabolism and activity on drug plasma and intracellular concentrations. Patients & methods: Rifampicin C-max and C-trough were measured at weeks 2 and 4 using Ultra-Performance Liquid Chromatographytandem mass spectroscopy methods. Allelic discrimination was performed by realtime polymerase chain reaction. Results: Twenty-four patients were enrolled. At week 2, OATP1B1 521TT and CYP27B1 + 2838CC/CT considering plasma and BsmIAA for intraperipheral blood mononuclear cells C-max, remained in regression analysis. Concerning week 4, TaqITC/CC and CYP24A1 22776CT/TT were retained in plasma C-max regression model. Conclusion: This study confirms the role of SLCO1B1 and it suggests the involvement of vitamin D pathway gene polymorphisms in rifampicin pharmacokinetics.

引用

页码：875 / 890

页数：16

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