Role of vitamin D pathway gene polymorphisms on rifampicin plasma and intracellular pharmacokinetics

被引：12
作者：
Allegra, Sarah [1 ]
Fatiguso, Giovanna [1 ]
Calcagno, Andrea [1 ]
Baietto, Lorena [1 ]
Motta, Ilaria [1 ]
Favata, Fabio [1 ]
Cusato, Jessica [1 ]
Bonora, Stefano [1 ]
Di Perri, Giovanni [1 ]
D'Avolio, Antonio [1 ]
机构：
[1] Univ Turin, Unit Infect Dis, Lab Clin Pharmacol & Pharmacogenet, Amedeo Savoia Hosp,Dept Med Sci, Corso Svizzera 164, I-10149 Turin, Italy
来源：
PHARMACOGENOMICS | 2017年 / 18卷 / 09期
关键词：
ABCB1; Cdx2; CYP24A1; FokI; pharmacokinetics; TaqI; tuberculosis; D-RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISMS; SLCO1B1; POLYMORPHISM; MDR1; GENE; MYCOBACTERIUM-TUBERCULOSIS; 1,25-DIHYDROXYVITAMIN D-3; IMMUNE-SYSTEM; CUTTING EDGE; EXPRESSION; DRUG;
D O I：
10.2217/pgs-2017-0176
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We retrospectively evaluate the pharmacogenetic role of single nucleotide polymorphisms involved in rifampicin transport (SLCO1B1, MDR1 and PXR genes) and vitamin D (VDR, CYP24A1 and CYP27B1 genes) metabolism and activity on drug plasma and intracellular concentrations. Patients & methods: Rifampicin C-max and C-trough were measured at weeks 2 and 4 using Ultra-Performance Liquid Chromatographytandem mass spectroscopy methods. Allelic discrimination was performed by realtime polymerase chain reaction. Results: Twenty-four patients were enrolled. At week 2, OATP1B1 521TT and CYP27B1 + 2838CC/CT considering plasma and BsmIAA for intraperipheral blood mononuclear cells C-max, remained in regression analysis. Concerning week 4, TaqITC/CC and CYP24A1 22776CT/TT were retained in plasma C-max regression model. Conclusion: This study confirms the role of SLCO1B1 and it suggests the involvement of vitamin D pathway gene polymorphisms in rifampicin pharmacokinetics.
引用
收藏
页码：875 / 890
页数：16
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