A total synthesis of a new class of biazine thioglycosides

被引：24

作者：

Elgemeie, GH

Hussein, MM

Al-Khursani, SA

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[3] Girls Coll Sci, Dept Chem, Dammam, Saudi Arabia

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2004年 / 23卷 / 8-9期

关键词：

bipyridinyl thioglycosides; biazine thioglycosides; antimetabolites;

D O I：

10.1081/CAR-200045262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new method for the synthesis of bipyridinyl S-glycosides 11 and 12 has provided the title compounds in a higher yield. Application of a one-pot glycosylation methodology resulted in an efficient, high-yield synthesis of biazine S-glycosides 17-20 An X-ray diffraction analysis of 11 disclosed the conformation of this glycoside as the S-glycoside and not the corresponding N-form.

引用

页码：465 / 481

页数：17

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