Hydrogel formation by radiation induced crosslinked copolymerization of acrylamide onto moringa gum for use in drug delivery applications

Keeping in view the importance of polysaccharides gum in designing drug delivery systems, the present work is the exploration of the potential of the moringa gum in hydrogel formation via radiation induced crosslinking method for drug delivery applications. These polymers were characterized by cryo-SEM, AFM, FTIR, C-13-NMR spectroscopy and swelling studies. Some properties of the polymers such as blood compatibility, antioxidant activity, mucoadhesion and gel strength were also determined along with the evaluation of drug release profile of an antibiotic drug levofloxacin. The slow release of drug was observed without burst effect from the drug loaded hydrogels. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas kinetic model. Cryo-SEM showed the porous nature of the hydrogels. The polymers were found to be mucoadhesive and antioxidant in nature. These results indicated that these pure and sterile polymers can be proposed as gastrointestinal drug delivery system.