Free-radical and biochemical reactions involving polar part of glycerophospholipids

被引：18

作者：

Shadyro, Oleg ^{[1
,2
]}

Samovich, Svetlana ^{[1
,2
]}

Edimecheva, Irina ^{[2
]}

机构：

[1] Belarusian State Univ, Dept Chem, Nezavisimosti Av 4, Minsk 220030, BELARUS

[2] Belarusian State Univ, Res Inst Phys & Chem Problems, Leningradskaya St 14, Minsk 220050, BELARUS

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2019年 / 144卷

关键词：

Glycerophospholipids; Free-radical fragmentation; Phospholipases; Inhibitors; O-GLYCOSIDE BOND; PHOSPHATIDIC-ACID; PHOSPHOLIPASE-D; INOSITOL TRISPHOSPHATE; HOMOLYTIC CLEAVAGE; ASCORBIC-ACID; FRAGMENTATION; MODEL; MECHANISM; CHEMISTRY;

D O I：

10.1016/j.freeradbiomed.2019.02.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review summarizes and critically discusses data on biochemical and free-radical transformations of glycerophospholipids. The results presented therein demonstrate that hydroxyl-containing glycerophospholipids, such as cardiolipin, lyso-lipids and others, can undergo fragmentation upon interaction with radical agents forming the biologically active products. Hydrolysis of glycerophospholipids catalyzed by different phospholi-pases was shown to yield compounds, which can be involved in the free-radical fragmentation leading to significant changes in structures of original lipids.

引用

页码：6 / 15

页数：10

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