A straightforward method for the synthesis of alkylidene and arylidene malonates through proline-catalyzed knoevenagel condensation

被引：99

作者：

Cardillo, G ^{[1
]}

Fabbroni, S ^{[1
]}

Gentilucci, L ^{[1
]}

Gianotti, M ^{[1
]}

Tolomelli, A ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 09期

关键词：

knoevenagel condensation; proline; alkylidene malonate; arylidene malonate; arylidene cyanoacetate;

D O I：

10.1081/SCC-120018782

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents.

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页码：1587 / 1594

页数：8

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