Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis

被引:20
作者
Mikic, Aleksandra Novakov [1 ]
Budakov, Dragan [1 ]
机构
[1] Clin Ctr Vojvodina, Dept Obstet & Gynaecol, Novi Sad 21000, Serbia
关键词
Bacterial vaginosis; Metronidazole; Octenidine hydrochloride; Phenoxyethanol; VAGINAL INFECTIONS; ORAL METRONIDAZOLE; VAGINITIS; CLINDAMYCIN;
D O I
10.1007/s00404-009-1241-7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Bacterial vaginosis (BV) is characterized by a mixed flora of pathogenic anaerobic bacteria and associated with risks of pathologic conditions. In the present study, therapy with a local antiseptic spray (octenidine hydrochloride/phenoxyethanol, OHP) for 7 or 14 days is compared against the standard local therapy of BV (metronidazole) in a Serbian patient population. As much as 450 women were treated in groups with either 7 days metronidazole vaginal tablets, 7 days OHP, or 14 days OHP. Control smears were taken after each treatment period. In total, 63.2% of the women were without indications of BV after therapy (metronidazole: 61.0%, OHP 7 days: 57.6%, and OHP 14 days: 71.0%). Significantly fewer women were affected from infections after treatment with 14 days OHP compared to OHP for 7 days. Octenidine hydrochloride/phenoxyethanol spray was as effective as the standard therapy with metronidazole. Patients stated that OHP was more comfortable, easier to apply, and side effects were lesser.
引用
收藏
页码:43 / 47
页数:5
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