Potential regulatory mechanisms of lncRNA in diabetes and its complications

被引：62

作者：

Feng, Shui-Dong ^{[1
]}

Yang, Ji-Hua ^{[2
]}

Yao, Chao Hua ^{[3
]}

Yang, Si-Si ^{[2
]}

Zhu, Ze-Mei ^{[2
]}

Wu, Di ^{[2
]}

Ling, Hong-Yan ^{[2
]}

Zhang, Liang ^{[3
]}

机构：

[1] Univ South China, Sch Publ Hlth, Dept Social Med & Hlth Serv Management, Hengyang, Peoples R China

[2] Univ South China, Sch Med, Dept Physiol, Hengyang, Peoples R China

[3] Palmer Ctr Chiropract Res, Lab Cell & Mol Biol, Port Orange, FL 32129 USA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2017年 / 95卷 / 03期

关键词：

lncRNA; diabetes; diabetic complications; LONG NONCODING RNA; GROWTH-FACTOR-BETA; STAGE RENAL-DISEASE; INSULIN-SECRETION; PANCREATIC-ISLETS; DOWN-REGULATION; CELL FUNCTION; GLUCOSE; GENE; EXPRESSION;

D O I：

10.1139/bcb-2016-0110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs ( lncRNAs) are transcripts longer than 200 nucleotides without protein-coding potential. Although these molecules were initially considered as "junk products" of transcription without biological relevance, recent advances in research have shown that lncRNA plays an important role, not only in cellular processes such as proliferation, differentiation, and metabolism, but also in the pathological processes of cancers, diabetes, and neurodegenerative diseases. In this review, we focus on the potential regulatory roles of lncRNA in diabetes and the complications associated with diabetes.

引用

页码：361 / 367

页数：7

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