Blueprint for pandemic response: Focus on translational medicine, clinical pharmacology and pharmacometrics

被引:3
|
作者
Davda, Jasmine [1 ]
Reynolds, Kellie [2 ]
Davis, John D. [3 ]
Smith, Patrick F. [1 ]
机构
[1] Certara, 101 Overlook Ctr, Princeton, NJ 08540 USA
[2] US FDA, Div Infect Dis Pharmacol DIDP, Off Clin Pharmacol OCP, Ctr Drug Evaluat & Res,Off Translat Sci OTS, Silver Spring, MD USA
[3] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
关键词
clinical pharmacology; COVID-19; pandemic; pharmacometrics; virology; CONVALESCENT PLASMA; ANTIVIRAL USE; ANTIBODY; PHARMACOKINETICS; EPIDEMIOLOGY; VIRUS;
D O I
10.1111/bcp.14859
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Perhaps the most important lesson learned from the COVID-19 pandemic is that of preparedness. Enhanced surveillance systems for early threat detection will be crucial to maximizing response time for implementation of public health measures and mobilization of resources in containing an emerging pandemic. Recent outbreaks have been dominated by viral pathogens, with RNA respiratory viruses being the most likely to have pandemic potential. These should therefore be a preparedness priority. Tools in the areas of virology, drug discovery, clinical pharmacology, translational medicine and pharmacometrics should be considered key components in the rapid identification and development of existing and novel interventions for a pandemic response. Prioritization of therapeutics should be based on in vitro activity, likelihood of achieving effective drug concentrations at the site of action, and safety profile at the doses that will be required for clinical efficacy. Deployment strategies must be tailored to the epidemiology of the disease, and the adequacy of the response should be re-evaluated in view of evolving epidemiological factors. An interdisciplinary framework integrating drug pharmacology, viral kinetics, epidemiology and health economics could help optimize the deployment strategy by improving decision-making around who to treat, when to treat, and with what type of intervention for optimal outcomes. Lastly, while an effective vaccine will ultimately end a pandemic, antiviral drug intervention guided by clinical pharmacology principles will continue to play a critical role in any pandemic response.
引用
收藏
页码:3398 / 3407
页数:10
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