Computational modeling and validation of intraventricular flow in a simple model of the left ventricle

被引：33

作者：

Vedula, Vijay ^{[1
]}

Fortini, Stefania ^{[2
]}

Seo, Jung-Hee ^{[1
]}

Querzoli, Giorgio ^{[3
]}

Mittal, Rajat ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA

[2] Univ Roma La Sapienza, Dipartimento Ingn Civile Edile & Ambientale, I-00184 Rome, Italy

[3] Univ Cagliari, Dipartimento Ingn Civile Ambientale & Architettur, I-09123 Cagliari, Italy

来源：

THEORETICAL AND COMPUTATIONAL FLUID DYNAMICS | 2014年 / 28卷 / 06期

基金：

美国国家科学基金会;

关键词：

Hemodynamics; Left ventricle; Immersed boundary method; Validation; Color M-mode; Vortex propagation; IMMERSED BOUNDARY METHOD; BLOOD-FLOW; PRESSURE-GRADIENTS; NUMERICAL-ANALYSIS; FLUID-MECHANICS; CARDIAC FLOW; HEART; VELOCITY; HYDRODYNAMICS; OPTIMIZATION;

D O I：

10.1007/s00162-014-0335-4

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

Simulations of flow inside a laboratory model of the left ventricle are validated against experiments. The simulations employ an immersed boundary-based method for flowmodeling, and the computationalmodel of the expanding-contracting ventricle is constructed via image-segmentation. A quantitative comparison of the phase-averaged velocity and vorticity fields between the simulation and the experiment shows a reasonable agreement, given the inherent uncertainties in the modeling procedure. Simulations also exhibit a good agreement in terms of time-varying net circulation, as well as clinically important metrics such as flow-wave propagation velocity and its ratio with peak early-wave flow velocity. The detailed and critical assessment of this comparison is used to identify and discuss the key challenges that are faced in such a validation study.

引用

页码：589 / 604

页数：16

共 46 条

[41] Experimental study of an asymmetric heart valve prototype
Vukicevic, M.
Fortini, S.
Querzoli, G.
Espa, S.
Pedrizzetti, G.
[J]. EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 2012, 35 : 54 - 60
[42] Cardiac Flow Analysis Applied to Phase Contrast Magnetic Resonance Imaging of the Heart
Wong, Kelvin K. L.
Kelso, Richard M.
Worthley, Stephen G.
Sanders, Prashanthan
Mazumdar, Jagannath
Abbott, Derek
[J]. ANNALS OF BIOMEDICAL ENGINEERING, 2009, 37 (08) : 1495 - 1515
[43] Constrained optimization of an idealized Y-shaped baffle for the Fontan surgery at rest and exercise
Yang, Weiguang
Feinstein, Jeffrey A.
Marsden, Alison L.
[J]. COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 2010, 199 (33-36) : 2135 - 2149
[44] A NON-STAGGERED GRID, FRACTIONAL STEP METHOD FOR TIME-DEPENDENT INCOMPRESSIBLE NAVIER-STOKES EQUATIONS IN CURVILINEAR COORDINATES
ZANG, Y
STREET, RL
KOSEFF, JR
[J]. JOURNAL OF COMPUTATIONAL PHYSICS, 1994, 114 (01) : 18 - 33
[45] A multi-fidelity modelling approach for evaluation and optimization of wing stroke aerodynamics in flapping flight
Zheng, Lingxiao
Hedrick, Tyson L.
Mittal, Rajat
[J]. JOURNAL OF FLUID MECHANICS, 2013, 721 : 118 - 154
[46] Computational modeling and analysis of intracardiac flows in simple models of the left ventricle
Zheng, X.
Seo, J. H.
Vedula, V.
Abraham, T.
Mittal, R.
[J]. EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 2012, 35 : 31 - 39

← 1 2 3 4 5 →