Computational modeling and validation of intraventricular flow in a simple model of the left ventricle

被引：35

作者：

Vedula, Vijay ^{[1
]}

Fortini, Stefania ^{[2
]}

Seo, Jung-Hee ^{[1
]}

Querzoli, Giorgio ^{[3
]}

Mittal, Rajat ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA

[2] Univ Roma La Sapienza, Dipartimento Ingn Civile Edile & Ambientale, I-00184 Rome, Italy

[3] Univ Cagliari, Dipartimento Ingn Civile Ambientale & Architettur, I-09123 Cagliari, Italy

来源：

THEORETICAL AND COMPUTATIONAL FLUID DYNAMICS | 2014年 / 28卷 / 06期

基金：

美国国家科学基金会;

关键词：

Hemodynamics; Left ventricle; Immersed boundary method; Validation; Color M-mode; Vortex propagation; IMMERSED BOUNDARY METHOD; BLOOD-FLOW; PRESSURE-GRADIENTS; NUMERICAL-ANALYSIS; FLUID-MECHANICS; CARDIAC FLOW; HEART; VELOCITY; HYDRODYNAMICS; OPTIMIZATION;

D O I：

10.1007/s00162-014-0335-4

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

Simulations of flow inside a laboratory model of the left ventricle are validated against experiments. The simulations employ an immersed boundary-based method for flowmodeling, and the computationalmodel of the expanding-contracting ventricle is constructed via image-segmentation. A quantitative comparison of the phase-averaged velocity and vorticity fields between the simulation and the experiment shows a reasonable agreement, given the inherent uncertainties in the modeling procedure. Simulations also exhibit a good agreement in terms of time-varying net circulation, as well as clinically important metrics such as flow-wave propagation velocity and its ratio with peak early-wave flow velocity. The detailed and critical assessment of this comparison is used to identify and discuss the key challenges that are faced in such a validation study.

引用

页码：589 / 604

页数：16

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