Asymmetric carbonyl reduction with borane catalyzed by chiral phosphinamides derived from L-amino acid

被引：28
作者：
Li, KY
Zhou, ZH
Wang, LX
Chen, QF
Zhao, GF
Zhou, QL
Tang, CC [1 ]
机构：
[1] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Cent Lab, Tianjin 300071, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0957-4166(02)00789-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two types of chiral phosphinamide catalysts 3a-d and 4a-c were prepared from L-phenylalanine and L-proline, respectively. Their applications in the asymmetric borane reduction of prochiral ketones were investigated. The chiral secondary alcohols were obtained with excellent chemical yields and moderate to high enantionteric excesses. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：95 / 100
页数：6
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