gem-Difluoropropargylation of aldehydes using cat.: In/Zn in aqueous media

被引：20

作者：

Arimitsu, Satoru ^{[1
]}

Jacobsen, Jesse M. ^{[1
]}

Hammond, Gerald B. ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 09期

基金：

美国国家科学基金会;

关键词：

cat; indium; zinc; aqueous media; gem-difluorohomopropargyl alcohols;

D O I：

10.1016/j.tetlet.2006.12.134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Zn (0.9 equiv) in combination with catalytic amounts of In (0.1 equiv) and I-2 (0.1 equiv) was found to effect the reaction of several difluoropropargyl bromide derivatives with aldehydes to produce gem-difluorohomopropargyl alcohols in aqueous media under conditions suitable for large scale applications. (c) 2007 Published by Elsevier Ltd.

引用

页码：1625 / 1627

页数：3

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