In vitro study of the anti-inflammatory activity of some medicinal and edible plants growing in Russia

被引：9

作者：

Kalinkevich, K. ^{[1
]}

Karandashov, V. E. ^{[1
]}

Ptitsyn, L. R. ^{[1
]}

机构：

[1] Ajinomoto Genet Res Inst, Moscow 117545, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2014年 / 40卷 / 07期

关键词：

anti-inflammatory; plant extracts; TNF-alpha assay; PGE(2) assay; NF-KAPPA-B; INFLAMMATION; CYCLOOXYGENASE-2; INHIBITORS; DISEASES; THERAPY; ORIGIN;

D O I：

10.1134/S106816201407005X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor alpha (TNF-alpha) and prostaglandin E-2 (PGE(2)) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-alpha and PGE(2) assays, respectively. We found that 16 plant extracts inhibited TNF-alpha production and 15 extracts decreased PGE(2) release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen, and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.

引用

页码：752 / 761

页数：10

共 34 条

[1] Molecular targets of dietary agents for prevention and therapy of cancer [J].