New benzophenone phosphonate derivatives

被引：3

作者：

Gaman, Maxim S. ^{[1
]}

Matyugina, Elena S. ^{[1
]}

Novikov, Mikhail S. ^{[2
]}

Babkov, Denis A. ^{[2
]}

Solyev, Pavel N. ^{[1
]}

Kochetkov, Sergey N. ^{[1
]}

Khandazhinskaya, Anastasia L. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Volgograd State Med Univ, Volgograd 400131, Russia

来源：

MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 04期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

REVERSE-TRANSCRIPTASE INHIBITORS; POTENT;

D O I：

10.1016/j.mencom.2017.07.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New well-soluble in 10% DMSO phosphonate derivatives of substituted benzophenone have been synthesized using different methods. Preliminary computer modeling of proposed structures in the reverse transcriptase HIV-1 hydrophobic pocket suggested these molecules as potential non-nucleoside inhibitors of this enzyme.

引用

页码：346 / 348

页数：3

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