Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea

被引：67

作者：

Hussein, Ahmed A.

Meyer, Jacobus J. M.

Jimeno, Maria L.

Rodriguez, Benjamin

机构：

[1] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

[2] Natl Res Ctr, Dept Chem Med Plants, Cairo, Egypt

[3] CSIC, Ctr Quim Organ Manuel Lora Tamayo, E-28006 Madrid, Spain

[4] Univ Pretoria, Dept Bot, ZA-0002 Pretoria, South Africa

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 02期

关键词：

D O I：

10.1021/np0680376

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanol extract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopic means. The ethanolic extract of Salvia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial (5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 mu M, respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 mu M, respectively, against a breast (MCF-7) human cancer cell line.

引用

页码：293 / 295

页数：3

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