NETs: a new strategy for using old weapons

被引:467
作者
Papayannopoulos, Venizelos [1 ]
Zychlinsky, Arturo [1 ]
机构
[1] Max Planck Inst Infect Biol, Dept Cellular Microbiol, Berlin, Germany
关键词
NEUTROPHIL EXTRACELLULAR TRAPS; LEUKOCYTE PROTEASE INHIBITOR; ALPHA-1-PROTEINASE INHIBITOR; STREPTOCOCCUS-PNEUMONIAE; ANTIMICROBIAL PEPTIDES; PROTEINASE-INHIBITOR; BACTERICIDAL ACTION; TISSUE-INJURY; ELASTASE; DNASE;
D O I
10.1016/j.it.2009.07.011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
As key players in the host innate immune response, neutrophils are recruited to sites of infection and constitute the first line of defense. They employ three strategies to eliminate invading microbes: microbial uptake, the secretion of antimicrobials, and the recently described release of Neutrophil Extracellular Traps (NETs). Composed of decondensed chromatin and antimicrobial proteins, NETs bind and kill a variety of microbes including bacteria, fungi, and parasites. In addition to using a repertoire of known antimicrobials, NETs incorporate histones into the antimicrobial arsenal. Furthermore, NETs may contribute to microbial containment by forming a physical barrier and a scaffold, to enhance antimicrobial synergy while minimizing damage to host tissues. Their role in innate immunity is only now being uncovered.
引用
收藏
页码:513 / 521
页数:9
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