Seroprevalence of SARS-CoV-2 antibody among urban Iranian population: findings from the second large population-based cross-sectional study

被引：9

作者：

Zamani, Mohammad ^{[1
]}

Poustchi, Hossein ^{[2
]}

Mohammadi, Zahra ^{[2
]}

Dalvand, Sahar ^{[2
]}

Sharafkhah, Maryam ^{[2
]}

Motevalian, Seyed Abbas ^{[3
,4
]}

Eslami, Saeid ^{[5
]}

Emami, Amir ^{[6
]}

Somi, Mohammad Hossein ^{[7
]}

Yazdani-Charati, Jamshid ^{[8
]}

Saki, Nader ^{[9
]}

Karami, Manoochehr ^{[10
,11
]}

Najafi, Farid ^{[12
]}

Mohebbi, Iraj ^{[13
]}

Veisi, Nasrollah ^{[14
]}

Hormati, Ahmad ^{[15
,16
]}

Pourfarzi, Farhad ^{[17
]}

Ghadimi, Reza ^{[18
]}

Ansari-Moghaddam, Alireza ^{[19
]}

Sharifi, Hamid ^{[20
,21
]}

Roshandel, Gholamreza ^{[22
]}

Mansour-Ghanaei, Fariborz ^{[23
]}

Joukar, Farahnaz ^{[24
]}

Shayanrad, Amaneh ^{[2
]}

Eghtesad, Sareh ^{[2
]}

Niavarani, Ahmadreza ^{[25
]}

Delavari, Alireza ^{[25
]}

Kaveh, Soudeh ^{[2
]}

Feizesani, Akbar ^{[2
]}

Markarian, Melineh ^{[1
]}

Shafighian, Fatemeh ^{[25
]}

Sadjadi, Alireza ^{[25
]}

Darvishian, Maryam ^{[26
]}

Malekzadeh, Reza ^{[1
,25
]}

机构：

[1] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Ctr, Digest Dis Res Inst, Tehran 1411713135, Iran

[2] Univ Tehran Med Sci, Shariati Hosp, Liver & Pancreatobiliary Dis Res Ctr, Digest Dis Res Inst, Tehran, Iran

[3] Iran Univ Med Sci, Res Ctr Addict & Risky Behav ReCARB, Psychosocial Hlth Res Inst, Tehran, Iran

[4] Iran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran

[5] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[6] Shiraz Univ Med Sci, Burn & Wound Healing Res Ctr, Microbiol Dept, Shiraz, Iran

[7] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[8] Mazandaran Univ Med Sci, Fac Hlth, Hlth Sci Res Ctr, Addict Inst,Dept Biostat, Sari, Iran

[9] Ahvaz Jundishapur Univ Med, Hearing Res Ctr, Ahvaz, Iran

[10] Hamadan Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Hamadan, Iran

[11] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Epidemiol, Tehran, Iran

[12] Kermanshah UMS, Sch Publ Hlth, Res Ctr Environm Determinants Hlth, Kermanshah, Iran

[13] Urmia Univ Med Sci, Social Determinants Hlth Ctr, Orumiyeh, Iran

[14] Kurdistan Univ Med Sci, Sanandaj, Iran

[15] Qom Univ Med Sci, Gastroenterol & Hepatol Dis Res Ctr, Qom, Iran

[16] Iran Univ Med Sci, Sch Med, Gastrointestinal & Liver Dis Res Ctr, Dept Internal Med, Tehran, Iran

[17] Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran

[18] Babol Univ Med Sci, Hlth Res Inst, Social Determinants Hlth Res Ctr, Babol, Iran

[19] Zahedan Univ Med Sci, Hlth Promot Res Ctr, Zahedan, Iran

[20] Kerman Univ Med Sci, HIV STI Surveillance Res Ctr, Inst Futures Studies Hlth, Kerman, Iran

[21] Kerman Univ Med Sci, Who Collaborating Ctr HIV Surveillance, Inst Futures Studies Hlth, Kerman, Iran

[22] Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Golestan, Iran

[23] Guilan Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Div Gastroenterol & Hepatol, Rasht, Iran

[24] Guilan Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Rasht, Iran

[25] Univ Tehran Med Sci, Shariati Hosp, Digest Oncol Res Ctr, Digest Dis Res Inst, Tehran, Iran

[26] BC Canc Res Ctr, Canc Control Res, Vancouver, BC, Canada

来源：

BMC PUBLIC HEALTH | 2022年 / 22卷 / 01期

关键词：

COVID-19; SARS-CoV-2; Seroprevalence; General population; Infection; POLICY;

D O I：

10.1186/s12889-022-13464-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background The first large serosurvey in Iran found a SARS-CoV-2 antibody seroprevalence of 17.1% among the general population in the first wave of the epidemic by April, 2020. The purpose of the current study was to assess the seroprevalence of COVID-19 infection among Iranian general population after the third wave of the disease. Methods This population-based cross-sectional study was conducted on 7411 individuals aged >= 10 years old in 16 cities across 15 provinces in Iran between January and March, 2021. We randomly sampled individuals registered in the Iranian electronic health record system based on their national identification numbers and invited them by telephone to a healthcare center for data collection. Presence of SARS-CoV-2-specific IgG and IgM antibodies was assessed using the SARS-CoV-2 ELISA kits. The participants were also asked about their recent COVID-19-related symptoms, including cough, fever, chills, sore throat, headache, dyspnea, diarrhea, anosmia, conjunctivitis, weakness, myalgia, arthralgia, altered level of consciousness, and chest pain. The seroprevalence was estimated after adjustment for population weighting and test performance. Results The overall population-weighted seroprevalence adjusted for test performance was 34.2% (95% CI 31.0-37.3), with an estimated 7,667,874 (95% CI 6,950,412-8,362,915) infected individuals from the 16 cities. The seroprevalence varied between the cities, from the highest estimate in Tabriz (39.2% [95% CI 33.0-45.5]) to the lowest estimate in Kerman (16.0% [95% CI 10.7-21.4]). In the 16 cities studied, 50.9% of the seropositive individuals did not report a history of symptoms suggestive of COVID-19, implying an estimation of 3,902,948 (95% CI 3,537,760-4,256,724) asymptomatic infected individuals. Conclusions Nearly one in three individuals were exposed to SARS-CoV-2 in the studied cities by March 2021. The seroprevalence increased about two-fold between April, 2020, and March, 2021.

引用

页数：10

共 50 条

[11] Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study [J].

de Souza Araujo, Adriano Antunes ;

Quintans-Junior, Lucindo Jose ;

Heimfarth, Luana ;

Schimieguel, Dulce Marta ;

Correa, Cristiane Bani ;

de Moura, Tatiana Rodrigues ;

Cavalcante, Rafael Ciro Marques ;

Rodrigues Bomfim, Rangel ;

Grespan, Renata ;

Santana Rodrigues, Lorranny ;

dos Santos, Danillo Menezes ;

de Sa Resende, Ayane ;

de Lima Silva, Nathanielly ;

da Silva Santos, Anna Clara Ramos ;

Dantas Araujo, Jessica Maria ;

de Souza, Mercia Feitosa ;

de Oliveira Goes, Marco Aurelio ;

Santana Santos, Victor ;

Martins-Filho, Paulo Ricardo .

EPIDEMIOLOGY AND INFECTION, 2021, 149

[12] SARS-CoV-2 population-based seroprevalence studies in Europe: a scoping review [J].

Grant, Rebecca ;

Dub, Timothee ;

Andrianou, Xanthi ;

Nohynek, Hanna ;

Wilder-Smith, Annelies ;

Pezzotti, Patrizio ;

Fontanet, Arnaud .

BMJ OPEN, 2021, 11 (04)

[13] Persistent symptoms after SARS-CoV-2 infection in children: a cross-sectional population-based serological study [J].

Dumont, Roxane ;

Nehme, Mayssam ;

Lorthe, Elsa ;

De Mestral, Carlos ;

Richard, Viviane ;

Baysson, Helene ;

Pennacchio, Francesco ;

Lamour, Julien ;

Semaani, Claire ;

Zaballa, Maria-Eugenia ;

Pullen, Nick ;

Perrin, Anne ;

L'Huillier, Arnaud G. ;

Posfay-Barbe, Klara Maria ;

Guessous, Idris ;

Stringhini, Silvia .

BMJ OPEN, 2022, 12 (11)

[14] Seroprevalence and factors associated with SARS-CoV-2 infection among healthcare workers: cross-sectional study [J].

Taher, Watheq Thabet ;

Bawazir, Amen A. ;

Sallam, Talal A. ;

Alsurimi, Khaled .

BMC INFECTIOUS DISEASES, 2023, 23 (01)

[15] Seroprevalence and factors associated with SARS-CoV-2 infection among healthcare workers: cross-sectional study [J].

Watheq Thabet Taher ;

Amen A. Bawazir ;

Talal A. Sallam ;

Khaled Alsurimi .

BMC Infectious Diseases, 23

[16] SARS-CoV-2 seroprevalence and associated risk factors in periurban Zambia: a population-based study [J].

Shanaube, K. ;

Schaap, A. ;

Klinkenberg, E. ;

Floyd, S. ;

Bwalya, J. ;

Cheeba, M. ;

de Haas, P. ;

Kosloff, B. ;

Ruperez, M. ;

Hayes, R. ;

Ayles, H. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 118 :256-263

[17] SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study [J].

Backhaus, I ;

Hermsen, D. ;

Timm, J. ;

Boege, F. ;

Luebke, N. ;

Degode, T. ;

Goebels, K. ;

Dragano, N. .

PUBLIC HEALTH, 2022, 207 :54-61

[18] Severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in Lebanon: a population-based cross-sectional study [J].

Mahdi, Ahmad ;

Khazen, Georges ;

Aziz, Nivine ;

Mina, Jonathan ;

Papazian, Aram ;

Daou, Leonardo ;

Ahmar, Jana ;

Assaf, Nour ;

Abdulkhalek, Anjy ;

Farhat, Hussein ;

Farra, Anna ;

Husni, Rola .

IJID REGIONS, 2022, 2 :184-190

[19] Serological survey to estimate SARS-CoV-2 infection and antibody seroprevalence at a large public university: A cross-sectional study [J].

Hou, Ching-Wen ;

Williams, Stacy ;

Taylor, Kylee ;

Boyle, Veronica ;

Bobbett, Bradley ;

Kouvetakis, Joseph ;

Nguyen, Keana ;

McDonald, Aaron ;

Harris, Valerie ;

Nussle, Benjamin ;

Scharf, Phillip ;

Jehn, Megan L. ;

Lant, Timothy ;

Magee, Mitchell ;

Chung, Yunro ;

LaBaer, Joshua ;

Murugan, Vel .

BMJ OPEN, 2023, 13 (08)

[20] Population-based repeat cross-sectional seroprevalence survey of SARS-CoV-2 IgG antibodies in Pimpri Chinchwad Municipal Corporation Area, Maharashtra, India [J].

Bawa, Mukesh S. ;

Desale, Atul, V ;

Pandve, Harshal T. ;

Nimbalkar, Abhijit, V ;

Patil, Tushar, V ;

Gophane, Laxman P. ;

Dadewar, Abhaychandra A. ;

Thatkar, Pandurang ;

Dhage, Shivaji T. ;

Kharat, Medha K. ;

Bhaysar, Shailaja M. ;

Firke, Rajendra P. ;

Ambedkar, Vijaya A. ;

Salve, Sunita S. ;

Sagale, Trupti M. .

JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2022, 11 (06) :2789-2793

← 1 2 3 4 5 →